MicroRNAs in skeletal myogenesis

Yejing Ge, Jie Chen

Research output: Contribution to journalReview article

Abstract

MicroRNAs (miRNAs) have emerged as critical regulators of numerous biological processes by modulating gene expression at the post-transcriptional level. It has become increasingly clear that almost all aspects of skeletal muscle development involve regulation by miRNAs. Many of these miRNAs have distinct expression profiles in skeletal muscles, under the regulation by the myogenic program. In the last few years the field has seen a rapid expansion of our knowledge of myogenic miRNAs that target a wide range of muscle genes to coordinately control the myogenic process. In this review we provide an up-to-date list of reported myogenic miRNAs and survey their expression patterns, regulation of biogenesis and gene targets in skeletal muscles. Emerging themes of miRNA regulation in the context of skeletal myogenesis will also be discussed.

Original languageEnglish (US)
Pages (from-to)441-448
Number of pages8
JournalCell Cycle
Volume10
Issue number3
DOIs
StatePublished - Feb 1 2011

Keywords

  • Feedback
  • MicroRNA
  • Muscle regeneration
  • Myoblast differentiation
  • Myogenesis
  • Skeletal muscle
  • miRNA expression
  • miRNA targets

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'MicroRNAs in skeletal myogenesis'. Together they form a unique fingerprint.

  • Cite this