MicroRNAs coordinate an alternative splicing network during mouse postnatal heart development

Auinash Kalsotra, Kun Wang, Pei Feng Li, Thomas A. Cooper

Research output: Contribution to journalArticlepeer-review

Abstract

Alternative splicing transitions have been identified recently as a conserved component of vertebrate heart remodeling during postnatal development. Here we report that the targeted deletion of Dicer, specifically in adult mouse myocardium, reveals the role of microRNAs (miRNAs) in regulating networks of postnatal splicing transitions and in maintaining adult splicing programs. We demonstrate a direct role for miR-23a/b in the dramatic postnatal down-regulation of CUGBP and ETR-3-like factor (CELF) proteins that regulate nearly half of developmentally regulated splicing transitions in the heart. These findings define a hierarchy in which rapid postnatal upregulation of specific miRNAs controls expression of alternative splicing regulators and the subsequent splicing transitions of their downstream targets.

Original languageEnglish (US)
Pages (from-to)653-658
Number of pages6
JournalGenes and Development
Volume24
Issue number7
DOIs
StatePublished - Apr 1 2010
Externally publishedYes

Keywords

  • Alternative splicing networks
  • CELF proteins
  • Heart development
  • MicroRNA

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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