Abstract
Alternative splicing transitions have been identified recently as a conserved component of vertebrate heart remodeling during postnatal development. Here we report that the targeted deletion of Dicer, specifically in adult mouse myocardium, reveals the role of microRNAs (miRNAs) in regulating networks of postnatal splicing transitions and in maintaining adult splicing programs. We demonstrate a direct role for miR-23a/b in the dramatic postnatal down-regulation of CUGBP and ETR-3-like factor (CELF) proteins that regulate nearly half of developmentally regulated splicing transitions in the heart. These findings define a hierarchy in which rapid postnatal upregulation of specific miRNAs controls expression of alternative splicing regulators and the subsequent splicing transitions of their downstream targets.
Original language | English (US) |
---|---|
Pages (from-to) | 653-658 |
Number of pages | 6 |
Journal | Genes and Development |
Volume | 24 |
Issue number | 7 |
DOIs | |
State | Published - Apr 1 2010 |
Externally published | Yes |
Keywords
- Alternative splicing networks
- CELF proteins
- Heart development
- MicroRNA
ASJC Scopus subject areas
- Genetics
- Developmental Biology