Microreactor and method for preparing a radiolabeled complex or a biomolecule conjugate

Tobias D Wheeler (Inventor), David E Reichert (Inventor), Amit V Desai (Inventor), Dexing Zeng (Inventor), Paul J A Kenis (Inventor), Birce C Onal (Inventor)

Research output: Patent

Abstract

A microreactor for preparing a radiolabeled complex or a biomolecule conjugate comprises a microchannel for fluid flow, where the microchannel comprises a mixing portion comprising one or more passive mixing elements, and a reservoir for incubating a mixed fluid. The reservoir is in fluid communication with the microchannel and is disposed downstream of the mixing portion. A method of preparing a radiolabeled complex includes flowing a radiometal solution comprising a metallic radionuclide through a downstream mixing portion of a microchannel, where the downstream mixing portion includes one or more passive mixing elements, and flowing a ligand solution comprising a bifunctional chelator through the downstream mixing portion. The ligand solution and the radiometal solution are passively mixed while in the downstream mixing portion to initiate a chelation reaction between the metallic radionuclide and the bifunctional chelator. The chelation reaction is completed to form a radiolabeled complex.
Original languageEnglish (US)
U.S. patent number8980185
StatePublished - Mar 17 2015

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