Microplasma Jet Arrays as a Therapeutic Choice for Fungal Keratitis

Hyun Jung Park; Soon Hee Kim; Hyung Woo Ju; Hyesook Lee; Yoonjin Lee; Sehyun Park; Heejun Yang; Sung Jin Park; J. Gary Eden; Jaewook Yang; Chan Hum Park

doi:10.1038/s41598-018-20854-8

Microplasma Jet Arrays as a Therapeutic Choice for Fungal Keratitis

Hyun Jung Park, Soon Hee Kim, Hyung Woo Ju, Hyesook Lee, Yoonjin Lee, Sehyun Park, Heejun Yang, Sung Jin Park, J. Gary Eden, Jaewook Yang, Chan Hum Park

Electrical and Computer Engineering

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Abstract

The clinical impact of microplasma jets on rabbit eyes infected by Candida albicans has been investigated. Arrays of such jets produce lowerature plasma micro-columns suitable for ophthalmic therapeutics and fungal infections, in particular, and the technology is capable of being scaled to surface areas of at least 10 cm². Keratitis was induced in the right central corneas of rabbits, whereas the left eyes served as a normal group. The rabbits were divided into the plasma non-treated group (control) and plasma treatment group. Histologic analyses of both groups showed marked reductions in the thickness, angiogenesis, and opacity of all rabbit corneas following plasma treatment. Indeed, for treatment times beyond 14 days, infected eyes exhibited no significant differences from the normal group. Healing of rabbit eyes infected by Candida albicans apparently proceeds by disrupting corneal epithelial proliferation, and by reducing fibrotic changes in the stroma. This study demonstrates that lowerature plasma jets are remarkably effective in healing Candida albicans-infected corneas, thereby providing a promising medical treatment option for keratitis.

Original language	English (US)
Article number	2422
Journal	Scientific reports
Volume	8
Issue number	1
DOIs	https://doi.org/10.1038/s41598-018-20854-8
State	Published - Dec 1 2018

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title = "Microplasma Jet Arrays as a Therapeutic Choice for Fungal Keratitis",

abstract = "The clinical impact of microplasma jets on rabbit eyes infected by Candida albicans has been investigated. Arrays of such jets produce lowerature plasma micro-columns suitable for ophthalmic therapeutics and fungal infections, in particular, and the technology is capable of being scaled to surface areas of at least 10 cm2. Keratitis was induced in the right central corneas of rabbits, whereas the left eyes served as a normal group. The rabbits were divided into the plasma non-treated group (control) and plasma treatment group. Histologic analyses of both groups showed marked reductions in the thickness, angiogenesis, and opacity of all rabbit corneas following plasma treatment. Indeed, for treatment times beyond 14 days, infected eyes exhibited no significant differences from the normal group. Healing of rabbit eyes infected by Candida albicans apparently proceeds by disrupting corneal epithelial proliferation, and by reducing fibrotic changes in the stroma. This study demonstrates that lowerature plasma jets are remarkably effective in healing Candida albicans-infected corneas, thereby providing a promising medical treatment option for keratitis.",

author = "Park, {Hyun Jung} and Kim, {Soon Hee} and Ju, {Hyung Woo} and Hyesook Lee and Yoonjin Lee and Sehyun Park and Heejun Yang and Park, {Sung Jin} and Eden, {J. Gary} and Jaewook Yang and Park, {Chan Hum}",

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doi = "10.1038/s41598-018-20854-8",

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AU - Park, Hyun Jung

AU - Kim, Soon Hee

AU - Ju, Hyung Woo

AU - Lee, Hyesook

AU - Lee, Yoonjin

AU - Park, Sehyun

AU - Yang, Heejun

AU - Park, Sung Jin

AU - Eden, J. Gary

AU - Yang, Jaewook

AU - Park, Chan Hum

PY - 2018/12/1

Y1 - 2018/12/1

N2 - The clinical impact of microplasma jets on rabbit eyes infected by Candida albicans has been investigated. Arrays of such jets produce lowerature plasma micro-columns suitable for ophthalmic therapeutics and fungal infections, in particular, and the technology is capable of being scaled to surface areas of at least 10 cm2. Keratitis was induced in the right central corneas of rabbits, whereas the left eyes served as a normal group. The rabbits were divided into the plasma non-treated group (control) and plasma treatment group. Histologic analyses of both groups showed marked reductions in the thickness, angiogenesis, and opacity of all rabbit corneas following plasma treatment. Indeed, for treatment times beyond 14 days, infected eyes exhibited no significant differences from the normal group. Healing of rabbit eyes infected by Candida albicans apparently proceeds by disrupting corneal epithelial proliferation, and by reducing fibrotic changes in the stroma. This study demonstrates that lowerature plasma jets are remarkably effective in healing Candida albicans-infected corneas, thereby providing a promising medical treatment option for keratitis.

AB - The clinical impact of microplasma jets on rabbit eyes infected by Candida albicans has been investigated. Arrays of such jets produce lowerature plasma micro-columns suitable for ophthalmic therapeutics and fungal infections, in particular, and the technology is capable of being scaled to surface areas of at least 10 cm2. Keratitis was induced in the right central corneas of rabbits, whereas the left eyes served as a normal group. The rabbits were divided into the plasma non-treated group (control) and plasma treatment group. Histologic analyses of both groups showed marked reductions in the thickness, angiogenesis, and opacity of all rabbit corneas following plasma treatment. Indeed, for treatment times beyond 14 days, infected eyes exhibited no significant differences from the normal group. Healing of rabbit eyes infected by Candida albicans apparently proceeds by disrupting corneal epithelial proliferation, and by reducing fibrotic changes in the stroma. This study demonstrates that lowerature plasma jets are remarkably effective in healing Candida albicans-infected corneas, thereby providing a promising medical treatment option for keratitis.

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Microplasma Jet Arrays as a Therapeutic Choice for Fungal Keratitis

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