Microfluidics-based lithography for fabricating ceramic and cell-laden microparticles

  • Priyadarshi Panda
  • , Robert F. Shepherd
  • , Zhihao Bao
  • , Samsher Ali
  • , Edward Lo
  • , Bong G. Chung
  • , Kenneth H. Sandhage
  • , Jennifer A. Lewis
  • , Ali Khademhosseini
  • , T. Alan Hatton
  • , Patrick S. Doyle

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We developed stop-flow lithography (SFL) to generate 2-D extruded particles in a previous work [1]. In this work, we use SFL to generate ceramic microcompo-nents from colloidal building blocks for microelectromechanical systems (MEMS) and cell-laden microgel particles for potential applications in tissue engineering. The colloidal particles generated by passing an index matched solution of colloidal silica with acrylamide solution through a microchannel, were sintered to make silica microgears followed by conversion to silicon microgears using magnesiothermic re-duction [2]. Cell-laden microparticles of different shapes were also synthesized. The cell viability for these gels was ∼ 68%.

Original languageEnglish (US)
Title of host publication12th International Conference on Miniaturized Systems for Chemistry and Life Sciences - The Proceedings of MicroTAS 2008 Conference
PublisherChemical and Biological Microsystems Society
Pages659-661
Number of pages3
StatePublished - 2008
Event12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008 - San Diego, CA, United States
Duration: Oct 12 2008Oct 16 2008

Other

Other12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008
Country/TerritoryUnited States
CitySan Diego, CA
Period10/12/0810/16/08

Keywords

  • Cell-encapsulation
  • Ceramics
  • Microelectromechanical systems
  • Microfluidics

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

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