Microfluidics-based lithography for fabricating ceramic and cell-laden microparticles

Priyadarshi Panda, Robert F. Shepherd, Zhihao Bao, Samsher Ali, Edward Lo, Bong G. Chung, Kenneth H. Sandhage, Jennifer A. Lewis, Ali Khademhosseini, T. Alan Hatton, Patrick S. Doyle

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We developed stop-flow lithography (SFL) to generate 2-D extruded particles in a previous work [1]. In this work, we use SFL to generate ceramic microcompo-nents from colloidal building blocks for microelectromechanical systems (MEMS) and cell-laden microgel particles for potential applications in tissue engineering. The colloidal particles generated by passing an index matched solution of colloidal silica with acrylamide solution through a microchannel, were sintered to make silica microgears followed by conversion to silicon microgears using magnesiothermic re-duction [2]. Cell-laden microparticles of different shapes were also synthesized. The cell viability for these gels was ∼ 68%.

Original languageEnglish (US)
Title of host publication12th International Conference on Miniaturized Systems for Chemistry and Life Sciences - The Proceedings of MicroTAS 2008 Conference
PublisherChemical and Biological Microsystems Society
Pages659-661
Number of pages3
StatePublished - Jan 1 2008
Event12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008 - San Diego, CA, United States
Duration: Oct 12 2008Oct 16 2008

Other

Other12th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2008
CountryUnited States
CitySan Diego, CA
Period10/12/0810/16/08

Keywords

  • Cell-encapsulation
  • Ceramics
  • Microelectromechanical systems
  • Microfluidics

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

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