Microfluidic technology for assisted reproduction

D. Beebe; M. Wheeler; H. Zeringue; E. Walters; S. Raty

doi:10.1016/S0093-691X(01)00662-8

Microfluidic technology for assisted reproduction

D. Beebe, M. Wheeler, H. Zeringue, E. Walters, S. Raty

Research output: Contribution to journal › Article › peer-review

Abstract

The physical tools used in assisted reproduction have changed little over several decades. Microfluidics is an emerging technology that allows a fresh examination of the way assisted reproduction is performed. Here we review our work to develop microfluidic devices to perform the functions required in assisted reproduction. These functions include loading/unloading, culture, chemical manipulation, and mechanical manipulation of embryos and oocytes. Basic microfluidic theory and microfluidic device design and operation are discussed. Results are presented for mechanical removal of cumulus cells and for embryo culture. Results suggest that microfluidic systems will lead to improved efficiencies in assisted reproduction.

Original language	English (US)
Pages (from-to)	125-135
Number of pages	11
Journal	Theriogenology
Volume	57
Issue number	1
DOIs	https://doi.org/10.1016/S0093-691X(01)00662-8
State	Published - Jan 1 2002

Keywords

Bovine
Culture
Embryo
In vitro production
Livestock
Maturation
Microfluidic

ASJC Scopus subject areas

Animal Science and Zoology
General Veterinary

Online availability

10.1016/S0093-691X(01)00662-8

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title = "Microfluidic technology for assisted reproduction",

abstract = "The physical tools used in assisted reproduction have changed little over several decades. Microfluidics is an emerging technology that allows a fresh examination of the way assisted reproduction is performed. Here we review our work to develop microfluidic devices to perform the functions required in assisted reproduction. These functions include loading/unloading, culture, chemical manipulation, and mechanical manipulation of embryos and oocytes. Basic microfluidic theory and microfluidic device design and operation are discussed. Results are presented for mechanical removal of cumulus cells and for embryo culture. Results suggest that microfluidic systems will lead to improved efficiencies in assisted reproduction.",

keywords = "Bovine, Culture, Embryo, In vitro production, Livestock, Maturation, Microfluidic",

author = "D. Beebe and M. Wheeler and H. Zeringue and E. Walters and S. Raty",

note = "Funding Information: ACKNOWLEDGMENTS Thanks are extended to Rick Monson and Jack Rutledge, Department of Animal Sciences, University of Wisconsin-Madison (Madison, WI 53706) for supplying bovine oocyte-cumulus complexes used in the cumulus removal work. Funding for this project was provided by the Illinois Council on Food and Agricultural Research, University of Illinois Critical Research Initiatives, University of Wisconsin - Madison, USDA, and Vitae LLC, Madison, WI.",

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AU - Wheeler, M.

AU - Zeringue, H.

AU - Walters, E.

AU - Raty, S.

N1 - Funding Information: ACKNOWLEDGMENTS Thanks are extended to Rick Monson and Jack Rutledge, Department of Animal Sciences, University of Wisconsin-Madison (Madison, WI 53706) for supplying bovine oocyte-cumulus complexes used in the cumulus removal work. Funding for this project was provided by the Illinois Council on Food and Agricultural Research, University of Illinois Critical Research Initiatives, University of Wisconsin - Madison, USDA, and Vitae LLC, Madison, WI.

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N2 - The physical tools used in assisted reproduction have changed little over several decades. Microfluidics is an emerging technology that allows a fresh examination of the way assisted reproduction is performed. Here we review our work to develop microfluidic devices to perform the functions required in assisted reproduction. These functions include loading/unloading, culture, chemical manipulation, and mechanical manipulation of embryos and oocytes. Basic microfluidic theory and microfluidic device design and operation are discussed. Results are presented for mechanical removal of cumulus cells and for embryo culture. Results suggest that microfluidic systems will lead to improved efficiencies in assisted reproduction.

AB - The physical tools used in assisted reproduction have changed little over several decades. Microfluidics is an emerging technology that allows a fresh examination of the way assisted reproduction is performed. Here we review our work to develop microfluidic devices to perform the functions required in assisted reproduction. These functions include loading/unloading, culture, chemical manipulation, and mechanical manipulation of embryos and oocytes. Basic microfluidic theory and microfluidic device design and operation are discussed. Results are presented for mechanical removal of cumulus cells and for embryo culture. Results suggest that microfluidic systems will lead to improved efficiencies in assisted reproduction.

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KW - Embryo

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KW - Livestock

KW - Maturation

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Microfluidic technology for assisted reproduction

Abstract

Keywords

ASJC Scopus subject areas

Online availability

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