TY - JOUR
T1 - Microfluidic systems for single DNA dynamics
AU - Mai, Danielle J.
AU - Brockman, Christopher
AU - Schroeder, Charles M.
PY - 2012/11/7
Y1 - 2012/11/7
N2 - Recent advances in microfluidics have enabled the molecular-level study of polymer dynamics using single DNA chains. Single polymer studies based on fluorescence microscopy allow for the direct observation of non-equilibrium polymer conformations and dynamical phenomena such as diffusion, relaxation, and molecular stretching pathways in flow. Microfluidic devices have enabled the precise control of model flow fields to study the non-equilibrium dynamics of soft materials, with device geometries including curved channels, cross slots, and microfabricated obstacles and structures. This review explores recent microfluidic systems that have advanced the study of single polymer dynamics, while identifying new directions in the field that will further elucidate the relationship between polymer microstructure and bulk rheological properties.
AB - Recent advances in microfluidics have enabled the molecular-level study of polymer dynamics using single DNA chains. Single polymer studies based on fluorescence microscopy allow for the direct observation of non-equilibrium polymer conformations and dynamical phenomena such as diffusion, relaxation, and molecular stretching pathways in flow. Microfluidic devices have enabled the precise control of model flow fields to study the non-equilibrium dynamics of soft materials, with device geometries including curved channels, cross slots, and microfabricated obstacles and structures. This review explores recent microfluidic systems that have advanced the study of single polymer dynamics, while identifying new directions in the field that will further elucidate the relationship between polymer microstructure and bulk rheological properties.
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U2 - 10.1039/c2sm26036k
DO - 10.1039/c2sm26036k
M3 - Review article
AN - SCOPUS:84867364492
SN - 1744-683X
VL - 8
SP - 10560
EP - 10572
JO - Soft Matter
JF - Soft Matter
IS - 41
ER -