Microfluidic platforms for solid form screening of pharmaceuticals

Sachit Goyal, Michael R. Thorson, Yuchuan Gong, Geoff G Z Zhang, Paul J A Kenis

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This paper reports microfluidic platforms that enable screening for solid forms (salts, polymorphs) of pharmaceutical parent compounds (PCs) via diffusive mixing or solvent evaporation, and subsequent on-chip characterization using Raman spectroscopy. Key features of the reported platforms include combinatorial mixing to screen different conditions (24-48), improved solvent compatibility, minimal solvent loss, and improved control over solvent evaporation. These platforms allow for screening of many more conditions with a limited amount of PC (∼10 mg), thus facilitating solid form screening early in the drug development process. We validated the various platforms using model compounds such as ephedrine and tamoxi-fen.

Original languageEnglish (US)
Title of host publication15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Pages2089-2091
Number of pages3
StatePublished - Dec 1 2011
Event15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 - Seattle, WA, United States
Duration: Oct 2 2011Oct 6 2011

Publication series

Name15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Volume3

Other

Other15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
CountryUnited States
CitySeattle, WA
Period10/2/1110/6/11

Keywords

  • Combinatorial screening
  • Evaporation
  • Microfluidics
  • Pharmaceuticals
  • Raman spectroscopy
  • Salt formers

ASJC Scopus subject areas

  • Control and Systems Engineering

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  • Cite this

    Goyal, S., Thorson, M. R., Gong, Y., Zhang, G. G. Z., & Kenis, P. J. A. (2011). Microfluidic platforms for solid form screening of pharmaceuticals. In 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 (pp. 2089-2091). (15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011; Vol. 3).