@inproceedings{7422031ca83a4c6e9111dee9f952447f,
title = "Microfluidic platforms for solid form screening of pharmaceuticals",
abstract = "This paper reports microfluidic platforms that enable screening for solid forms (salts, polymorphs) of pharmaceutical parent compounds (PCs) via diffusive mixing or solvent evaporation, and subsequent on-chip characterization using Raman spectroscopy. Key features of the reported platforms include combinatorial mixing to screen different conditions (24-48), improved solvent compatibility, minimal solvent loss, and improved control over solvent evaporation. These platforms allow for screening of many more conditions with a limited amount of PC (∼10 mg), thus facilitating solid form screening early in the drug development process. We validated the various platforms using model compounds such as ephedrine and tamoxi-fen.",
keywords = "Combinatorial screening, Evaporation, Microfluidics, Pharmaceuticals, Raman spectroscopy, Salt formers",
author = "Sachit Goyal and Thorson, {Michael R.} and Yuchuan Gong and Zhang, {Geoff G Z} and Kenis, {Paul J A}",
year = "2011",
language = "English (US)",
isbn = "9781618395955",
series = "15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011",
pages = "2089--2091",
booktitle = "15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011",
note = "15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 ; Conference date: 02-10-2011 Through 06-10-2011",
}