Abstract

There is currently great interest in molecular therapies to treat various diseases, and this has prompted extensive efforts to achieve target-specific and controlled delivery of bioactive macromolecules (for example, proteins, antibodies, DNA and small interfering RNA) through the design of smart drug carriers. By contrast, the influence of the microenvironment in which the target cell resides and the effect it might have on the success of biomacromolecular therapies has been under-appreciated. The extracellular matrix (ECM) component of the cellular niche may be particularly important, as many diseases and injury disrupt the normal ECM architecture, the cell adhesion to ECM, and the subsequent cellular activities. This Review will discuss the importance of the ECM and the ECM-cell interactions on the cell response to bioactive macromolecules, and suggest how this information could lead to new criteria for the design of novel drug delivery systems.

Original languageEnglish (US)
Pages (from-to)455-463
Number of pages9
JournalNature Reviews Drug Discovery
Volume6
Issue number6
DOIs
StatePublished - Jun 1 2007

Fingerprint

Extracellular Matrix
Therapeutics
Drug Carriers
Drug Delivery Systems
Cell Adhesion
Cell Communication
Small Interfering RNA
Antibodies
DNA
Wounds and Injuries
Proteins

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

Cite this

Microenvironmental regulation of biomacromolecular therapies. / Kong, Hyun Joon; Mooney, David J.

In: Nature Reviews Drug Discovery, Vol. 6, No. 6, 01.06.2007, p. 455-463.

Research output: Contribution to journalReview article

@article{1cc12d3d26f3458f910d6dbecb2e0924,
title = "Microenvironmental regulation of biomacromolecular therapies",
abstract = "There is currently great interest in molecular therapies to treat various diseases, and this has prompted extensive efforts to achieve target-specific and controlled delivery of bioactive macromolecules (for example, proteins, antibodies, DNA and small interfering RNA) through the design of smart drug carriers. By contrast, the influence of the microenvironment in which the target cell resides and the effect it might have on the success of biomacromolecular therapies has been under-appreciated. The extracellular matrix (ECM) component of the cellular niche may be particularly important, as many diseases and injury disrupt the normal ECM architecture, the cell adhesion to ECM, and the subsequent cellular activities. This Review will discuss the importance of the ECM and the ECM-cell interactions on the cell response to bioactive macromolecules, and suggest how this information could lead to new criteria for the design of novel drug delivery systems.",
author = "Kong, {Hyun Joon} and Mooney, {David J.}",
year = "2007",
month = "6",
day = "1",
doi = "10.1038/nrd2309",
language = "English (US)",
volume = "6",
pages = "455--463",
journal = "Nature Reviews Drug Discovery",
issn = "1474-1776",
publisher = "Nature Publishing Group",
number = "6",

}

TY - JOUR

T1 - Microenvironmental regulation of biomacromolecular therapies

AU - Kong, Hyun Joon

AU - Mooney, David J.

PY - 2007/6/1

Y1 - 2007/6/1

N2 - There is currently great interest in molecular therapies to treat various diseases, and this has prompted extensive efforts to achieve target-specific and controlled delivery of bioactive macromolecules (for example, proteins, antibodies, DNA and small interfering RNA) through the design of smart drug carriers. By contrast, the influence of the microenvironment in which the target cell resides and the effect it might have on the success of biomacromolecular therapies has been under-appreciated. The extracellular matrix (ECM) component of the cellular niche may be particularly important, as many diseases and injury disrupt the normal ECM architecture, the cell adhesion to ECM, and the subsequent cellular activities. This Review will discuss the importance of the ECM and the ECM-cell interactions on the cell response to bioactive macromolecules, and suggest how this information could lead to new criteria for the design of novel drug delivery systems.

AB - There is currently great interest in molecular therapies to treat various diseases, and this has prompted extensive efforts to achieve target-specific and controlled delivery of bioactive macromolecules (for example, proteins, antibodies, DNA and small interfering RNA) through the design of smart drug carriers. By contrast, the influence of the microenvironment in which the target cell resides and the effect it might have on the success of biomacromolecular therapies has been under-appreciated. The extracellular matrix (ECM) component of the cellular niche may be particularly important, as many diseases and injury disrupt the normal ECM architecture, the cell adhesion to ECM, and the subsequent cellular activities. This Review will discuss the importance of the ECM and the ECM-cell interactions on the cell response to bioactive macromolecules, and suggest how this information could lead to new criteria for the design of novel drug delivery systems.

UR - http://www.scopus.com/inward/record.url?scp=34447525057&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34447525057&partnerID=8YFLogxK

U2 - 10.1038/nrd2309

DO - 10.1038/nrd2309

M3 - Review article

C2 - 17541418

AN - SCOPUS:34447525057

VL - 6

SP - 455

EP - 463

JO - Nature Reviews Drug Discovery

JF - Nature Reviews Drug Discovery

SN - 1474-1776

IS - 6

ER -