TY - JOUR
T1 - Microenvironmental regulation of biomacromolecular therapies
AU - Kong, Hyun Joon
AU - Mooney, David J.
N1 - Funding Information:
The authors thank the National Institutes of Health (R37 DE013033, R01 DE13349 and R01 HL069957) and the US Army Research Laboratories and Research Office (DAAD-19-03-1-0168) for financial support.
PY - 2007/6
Y1 - 2007/6
N2 - There is currently great interest in molecular therapies to treat various diseases, and this has prompted extensive efforts to achieve target-specific and controlled delivery of bioactive macromolecules (for example, proteins, antibodies, DNA and small interfering RNA) through the design of smart drug carriers. By contrast, the influence of the microenvironment in which the target cell resides and the effect it might have on the success of biomacromolecular therapies has been under-appreciated. The extracellular matrix (ECM) component of the cellular niche may be particularly important, as many diseases and injury disrupt the normal ECM architecture, the cell adhesion to ECM, and the subsequent cellular activities. This Review will discuss the importance of the ECM and the ECM-cell interactions on the cell response to bioactive macromolecules, and suggest how this information could lead to new criteria for the design of novel drug delivery systems.
AB - There is currently great interest in molecular therapies to treat various diseases, and this has prompted extensive efforts to achieve target-specific and controlled delivery of bioactive macromolecules (for example, proteins, antibodies, DNA and small interfering RNA) through the design of smart drug carriers. By contrast, the influence of the microenvironment in which the target cell resides and the effect it might have on the success of biomacromolecular therapies has been under-appreciated. The extracellular matrix (ECM) component of the cellular niche may be particularly important, as many diseases and injury disrupt the normal ECM architecture, the cell adhesion to ECM, and the subsequent cellular activities. This Review will discuss the importance of the ECM and the ECM-cell interactions on the cell response to bioactive macromolecules, and suggest how this information could lead to new criteria for the design of novel drug delivery systems.
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U2 - 10.1038/nrd2309
DO - 10.1038/nrd2309
M3 - Review article
C2 - 17541418
AN - SCOPUS:34447525057
SN - 1474-1776
VL - 6
SP - 455
EP - 463
JO - Nature Reviews Drug Discovery
JF - Nature Reviews Drug Discovery
IS - 6
ER -