TY - JOUR
T1 - Microbial sialidases
T2 - does bigger always mean better?
AU - Vimr, Eric R.
N1 - Funding Information:
SusanS teenbergenA, llison Hamilton and Laura Healy, are acknowledged gratefully. Special thanks are due to Bobby B. for alerting me to Vps Asp boxes, Eric Sixmister for the quote, See-Wing Chiu for molecular modeling and Kerry Helms for graphics. Due to space limitations, many primary references could not be cited; I apologize to any authors whose work was thus neglected. Work from my laboratory was supported by National Institutes of Health grant R01 AI23039.
PY - 1994/8
Y1 - 1994/8
N2 - Sialidases are a superfamily of N-acylneuraminate-releasing (sialic-acid-releasing) exoglycosidases found mainly in higher eukaryotes and in some, mostly pathogenic, viruses, bacteria and protozoans. The functions of sialidases are poorly understood and, until recently, their biochemical and evolutionary relationships were unclear. A comparative approach has demonstrated the remarkable similarities and differences between nonviral sialidases, and is providing clues about their functions.
AB - Sialidases are a superfamily of N-acylneuraminate-releasing (sialic-acid-releasing) exoglycosidases found mainly in higher eukaryotes and in some, mostly pathogenic, viruses, bacteria and protozoans. The functions of sialidases are poorly understood and, until recently, their biochemical and evolutionary relationships were unclear. A comparative approach has demonstrated the remarkable similarities and differences between nonviral sialidases, and is providing clues about their functions.
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U2 - 10.1016/0966-842X(94)90003-5
DO - 10.1016/0966-842X(94)90003-5
M3 - Review article
C2 - 7981969
AN - SCOPUS:0027993630
SN - 0966-842X
VL - 2
SP - 271
EP - 277
JO - Trends in Microbiology
JF - Trends in Microbiology
IS - 8
ER -