Microbial pathways in colonic sulfur metabolism and links with health and disease

Franck Carbonero, Ann C. Benefiel, Amir H. Alizadeh-Ghamsari, H. Rex Gaskins

Research output: Contribution to journalArticle

Abstract

Sulfur is both crucial to life and a potential threat to health. While colonic sulfur metabolism mediated by eukaryotic cells is relatively well studied, much less is known about sulfur metabolism within gastrointestinal microbes. Sulfated compounds in the colon are either of inorganic (e.g., sulfates, sulfites) or organic (e.g., dietary amino acids and host mucins) origin. The most extensively studied of the microbes involved in colonic sulfur metabolism are the sulfate-reducing bacteria (SRB), which are common colonic inhabitants. Many other microbial pathways are likely to shape colonic sulfur metabolism as well as the composition and availability of sulfated compounds, and these interactions need to be examined in more detail. Hydrogen sulfide is the sulfur derivative that has attracted the most attention in the context of colonic health, and the extent to which it is detrimental or beneficial remains in debate. Several lines of evidence point to SRB or exogenous hydrogen sulfide as potential players in the etiology of intestinal disorders, inflammatory bowel diseases (IBDs) and colorectal cancer in particular. Generation of hydrogen sulfide via pathways other than dissimilatory sulfate reduction may be as, or more, important than those involving the SRB. We suggest here that a novel axis of research is to assess the effects of hydrogen sulfide in shaping colonic microbiome structure. Clearly, in-depth characterization of the microbial pathways involved in colonic sulfur metabolism is necessary for a better understanding of its contribution to colonic disorders and development of therapeutic strategies.

Original languageEnglish (US)
Article numberArticle 448
JournalFrontiers in Physiology
Volume3 NOV
DOIs
StatePublished - Dec 17 2012

Fingerprint

Sulfur
Hydrogen Sulfide
Sulfates
Health
Bacteria
Sulfites
Microbiota
Eukaryotic Cells
Mucins
Inflammatory Bowel Diseases
Colorectal Neoplasms
Colon
Amino Acids
Research

Keywords

  • Colonic microbiota
  • Colorectal cancer
  • Hydrogen sulfide
  • Inflammatory bowel disease
  • Irritable bowel syndrome
  • Sulfate-reducing bacteria
  • Sulfur

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Microbial pathways in colonic sulfur metabolism and links with health and disease. / Carbonero, Franck; Benefiel, Ann C.; Alizadeh-Ghamsari, Amir H.; Gaskins, H. Rex.

In: Frontiers in Physiology, Vol. 3 NOV, Article 448, 17.12.2012.

Research output: Contribution to journalArticle

Carbonero, Franck ; Benefiel, Ann C. ; Alizadeh-Ghamsari, Amir H. ; Gaskins, H. Rex. / Microbial pathways in colonic sulfur metabolism and links with health and disease. In: Frontiers in Physiology. 2012 ; Vol. 3 NOV.
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