Methods for nano-mechanoporation

Kyungsuk Yum; Ning Wang; Min-Feng Yu

Methods for nano-mechanoporation

Kyungsuk Yum (Inventor)
, Ning Wang (Inventor)
, Min-Feng Yu (Inventor)

Mechanical Science and Engineering

Research output: Patent

Abstract

Methods for creating a transient nanoscale opening in a cell membrane and methods for transporting a desired species through the nanoscale opening are provided. A nano-sized needle-like tip can be used to mechanically slice the cell membrane to create a transient, localized nanoscale slit. The nanoscale slit may be used for transferring exogenous molecules into a living cell.

Original language	English (US)
U.S. patent number	8785177
Filing date	11/5/12
State	Published - Jul 22 2014

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title = "Methods for nano-mechanoporation",

abstract = "Methods for creating a transient nanoscale opening in a cell membrane and methods for transporting a desired species through the nanoscale opening are provided. A nano-sized needle-like tip can be used to mechanically slice the cell membrane to create a transient, localized nanoscale slit. The nanoscale slit may be used for transferring exogenous molecules into a living cell.",

author = "Kyungsuk Yum and Ning Wang and Min-Feng Yu",

note = "STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT This invention was made with government support under grant GM072744 awarded by National Institutes of Health and grant CBET-0933223 awarded by the National Science Foundation. The government has certain rights in the invention.; 8785177",

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T1 - Methods for nano-mechanoporation

AU - Yum, Kyungsuk

AU - Wang, Ning

AU - Yu, Min-Feng

N1 - STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT This invention was made with government support under grant GM072744 awarded by National Institutes of Health and grant CBET-0933223 awarded by the National Science Foundation. The government has certain rights in the invention.

PY - 2014/7/22

Y1 - 2014/7/22

N2 - Methods for creating a transient nanoscale opening in a cell membrane and methods for transporting a desired species through the nanoscale opening are provided. A nano-sized needle-like tip can be used to mechanically slice the cell membrane to create a transient, localized nanoscale slit. The nanoscale slit may be used for transferring exogenous molecules into a living cell.

AB - Methods for creating a transient nanoscale opening in a cell membrane and methods for transporting a desired species through the nanoscale opening are provided. A nano-sized needle-like tip can be used to mechanically slice the cell membrane to create a transient, localized nanoscale slit. The nanoscale slit may be used for transferring exogenous molecules into a living cell.

M3 - Patent

M1 - 8785177

Y2 - 2012/11/05

ER -

Methods for nano-mechanoporation

Abstract

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