Abstract

Metabolomics, the global characterisation of the small molecule complement involved in metabolism, has evolved into a powerful suite of approaches for understanding the global physiological and pathological processes occurring in biological organisms. The diversity of metabolites, the wide range of metabolic pathways and their divergent biological contexts require a range of methodological strategies and techniques. Methodologies for Metabolomics provides a comprehensive description of the newest methodological approaches in metabolomic research. The most important technologies used to identify and quantify metabolites, including nuclear magnetic resonance and mass spectrometry, are highlighted. The integration of these techniques with classical biological methods is also addressed. Furthermore, the book presents statistical and chemometric methods for evaluation of the resultant data. The broad spectrum of topics includes a vast variety of organisms, samples and diseases, ranging from in vivo metabolomics in humans and animals to in vitro analysis of tissue samples, cultured cells and biofluids.

Original languageEnglish (US)
PublisherCambridge University Press
Number of pages627
ISBN (Electronic)9780511996634
ISBN (Print)9780521765909
DOIs
StatePublished - Jan 1 2010

Fingerprint

Metabolomics
Metabolites
Physiological Phenomena
Pathologic Processes
Metabolic Networks and Pathways
Metabolism
Mass spectrometry
Cultured Cells
Mass Spectrometry
Animals
Magnetic Resonance Spectroscopy
Cells
Nuclear magnetic resonance
Tissue
Technology
Molecules
Research

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Methodologies for metabolomics : Experimental strategies and techniques. / Lutz, Norbert W.; Sweedler, Jonathan V; Wevers, Ron A.

Cambridge University Press, 2010. 627 p.

Research output: Book/ReportBook

Lutz, Norbert W. ; Sweedler, Jonathan V ; Wevers, Ron A. / Methodologies for metabolomics : Experimental strategies and techniques. Cambridge University Press, 2010. 627 p.
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