TY - BOOK
T1 - Methodologies for metabolomics
T2 - Experimental strategies and techniques
AU - Lutz, Norbert W.
AU - Sweedler, Jonathan V.
AU - Wevers, Ron A.
N1 - Publisher Copyright:
© Cambridge University Press 2013.
PY - 2010/1/1
Y1 - 2010/1/1
N2 - Metabolomics, the global characterisation of the small molecule complement involved in metabolism, has evolved into a powerful suite of approaches for understanding the global physiological and pathological processes occurring in biological organisms. The diversity of metabolites, the wide range of metabolic pathways and their divergent biological contexts require a range of methodological strategies and techniques. Methodologies for Metabolomics provides a comprehensive description of the newest methodological approaches in metabolomic research. The most important technologies used to identify and quantify metabolites, including nuclear magnetic resonance and mass spectrometry, are highlighted. The integration of these techniques with classical biological methods is also addressed. Furthermore, the book presents statistical and chemometric methods for evaluation of the resultant data. The broad spectrum of topics includes a vast variety of organisms, samples and diseases, ranging from in vivo metabolomics in humans and animals to in vitro analysis of tissue samples, cultured cells and biofluids.
AB - Metabolomics, the global characterisation of the small molecule complement involved in metabolism, has evolved into a powerful suite of approaches for understanding the global physiological and pathological processes occurring in biological organisms. The diversity of metabolites, the wide range of metabolic pathways and their divergent biological contexts require a range of methodological strategies and techniques. Methodologies for Metabolomics provides a comprehensive description of the newest methodological approaches in metabolomic research. The most important technologies used to identify and quantify metabolites, including nuclear magnetic resonance and mass spectrometry, are highlighted. The integration of these techniques with classical biological methods is also addressed. Furthermore, the book presents statistical and chemometric methods for evaluation of the resultant data. The broad spectrum of topics includes a vast variety of organisms, samples and diseases, ranging from in vivo metabolomics in humans and animals to in vitro analysis of tissue samples, cultured cells and biofluids.
UR - http://www.scopus.com/inward/record.url?scp=84925616239&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84925616239&partnerID=8YFLogxK
U2 - 10.1017/CBO9780511996634
DO - 10.1017/CBO9780511996634
M3 - Book
AN - SCOPUS:84925616239
SN - 9780521765909
BT - Methodologies for metabolomics
PB - Cambridge University Press
ER -