Method and apparatus for NMR spectroscopy of nanoliter volume samples

Jonathan V Sweedler (Inventor), Richard L Magin (Inventor), Timothy L Peck (Inventor), Andrew G Webb (Inventor), Nian Wu (Inventor)

Research output: Patent


A method and apparatus for structural elucidation and determination of a nanoliter size sample of analyte. The method includes separating the analyte using a microseparation technique and then substantially simultaneously analyzing or detecting the sample using a nuclear magnetic resonance (NMR) spectrometer. The apparatus includes an RF microcoil positioned for operable communication with a capillary member of the microseparation system and the NMR spectrometer to provide enhanced sensitivity and improved signal-to-noise ratio of the NMR spectrometer necessary to accurately analyze or detect nanoliter size samples.
Original languageEnglish (US)
U.S. patent number5654636
StatePublished - Aug 5 1997


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