Method and apparatus for NMR spectroscopy of nanoliter volume samples

Jonathan V Sweedler; Richard L Magin; Timothy L Peck; Andrew G Webb; Nian Wu

Method and apparatus for NMR spectroscopy of nanoliter volume samples

Jonathan V Sweedler (Inventor), Richard L Magin (Inventor), Timothy L Peck (Inventor), Andrew G Webb (Inventor), Nian Wu (Inventor)

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Abstract

A method and apparatus for structural elucidation and determination of a nanoliter size sample of analyte. The method includes separating the analyte using a microseparation technique and then substantially simultaneously analyzing or detecting the sample using a nuclear magnetic resonance (NMR) spectrometer. The apparatus includes an RF microcoil positioned for operable communication with a capillary member of the microseparation system and the NMR spectrometer to provide enhanced sensitivity and improved signal-to-noise ratio of the NMR spectrometer necessary to accurately analyze or detect nanoliter size samples.

Original language	English (US)
U.S. patent number	5654636
State	Published - Aug 5 1997

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title = "Method and apparatus for NMR spectroscopy of nanoliter volume samples",

abstract = "A method and apparatus for structural elucidation and determination of a nanoliter size sample of analyte. The method includes separating the analyte using a microseparation technique and then substantially simultaneously analyzing or detecting the sample using a nuclear magnetic resonance (NMR) spectrometer. The apparatus includes an RF microcoil positioned for operable communication with a capillary member of the microseparation system and the NMR spectrometer to provide enhanced sensitivity and improved signal-to-noise ratio of the NMR spectrometer necessary to accurately analyze or detect nanoliter size samples.",

author = "Sweedler, {Jonathan V} and Magin, {Richard L} and Peck, {Timothy L} and Webb, {Andrew G} and Nian Wu",

note = "This invention was made with Government support under NYI award CHE-9257024 and DIR-91 2419-2225 awarded by NSF. The Government has certain rights in the invention.; 5654636",

year = "1997",

month = aug,

day = "5",

language = "English (US)",

type = "Patent",

}

TY - PAT

T1 - Method and apparatus for NMR spectroscopy of nanoliter volume samples

AU - Sweedler, Jonathan V

AU - Magin, Richard L

AU - Peck, Timothy L

AU - Webb, Andrew G

AU - Wu, Nian

N1 - This invention was made with Government support under NYI award CHE-9257024 and DIR-91 2419-2225 awarded by NSF. The Government has certain rights in the invention.

PY - 1997/8/5

Y1 - 1997/8/5

N2 - A method and apparatus for structural elucidation and determination of a nanoliter size sample of analyte. The method includes separating the analyte using a microseparation technique and then substantially simultaneously analyzing or detecting the sample using a nuclear magnetic resonance (NMR) spectrometer. The apparatus includes an RF microcoil positioned for operable communication with a capillary member of the microseparation system and the NMR spectrometer to provide enhanced sensitivity and improved signal-to-noise ratio of the NMR spectrometer necessary to accurately analyze or detect nanoliter size samples.

AB - A method and apparatus for structural elucidation and determination of a nanoliter size sample of analyte. The method includes separating the analyte using a microseparation technique and then substantially simultaneously analyzing or detecting the sample using a nuclear magnetic resonance (NMR) spectrometer. The apparatus includes an RF microcoil positioned for operable communication with a capillary member of the microseparation system and the NMR spectrometer to provide enhanced sensitivity and improved signal-to-noise ratio of the NMR spectrometer necessary to accurately analyze or detect nanoliter size samples.

M3 - Patent

M1 - 5654636

ER -

Method and apparatus for NMR spectroscopy of nanoliter volume samples

Abstract

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