Metathesis reactions in total synthesis

K. C. Nicolaou, Paul G. Bulger, David Sarlah

Research output: Contribution to journalReview articlepeer-review


(Chemical Equation Presented) With the exception of palladium-catalyzed cross-couplings, no other group of reactions has had such a profound impact on the formation of carbon-carbon bonds and the art of total synthesis in the last quarter of a century than the metathesis reactions of olefins, enynes, and alkynes. Herein, we highlight a number of selected examples of total syntheses in which such processes played a crucial role and which imparted to these endeavors certain elements of novelty, elegance, and efficiency. Judging from their short but impressive history, the influence of these reactions in chemical synthesis is destined to increase.

Original languageEnglish (US)
Pages (from-to)4490-4527
Number of pages38
JournalAngewandte Chemie - International Edition
Issue number29
StatePublished - Jul 18 2005
Externally publishedYes


  • Alkene metathesis
  • Alkyne metathesis
  • Enyne metathesis
  • Natural products
  • Total synthesis

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)


Dive into the research topics of 'Metathesis reactions in total synthesis'. Together they form a unique fingerprint.

Cite this