Metabolic responses to protein supplementation and slaframine in goats and sheep fed roughage

H. R. Gaskins, W. J. Croom, J. M. Fernandez, J. E. van Eys, W. M. Hagler, W. L. Johnson

Research output: Contribution to journalArticle

Abstract

Eighteen grade Angora goats (BW 14 kg) and 18 Barbados Blackbelly × Dorset sheep (BW 24 kg), all wethers, were fed coastal bermudagrass hay (84% neutral detergent fiber, 6% crude protein) supplemented with alfalfa hay or cotton seed meal during an 84-day feeding trial. On day 28, daily treatment with slaframine (SF; 30 μg kg-1 BW), a parasympathomimetic with high affinity for the gastrointestinal tract, or physiological saline was initiated. On day 70, blood samples were obtained at hourly intervals for analyses of glucose (GLU), nonesterified fatty acids (NEFA), urea nitrogen (PUN), insulin (INS), glucagon (GLN), thyroxine (T4), and triiodothyronine uptake (T3U). Plasma concentrations of GLU, NEFA and PUN did not differ between species. Goats had higher (P < 0.05) concentrations of INS, T3, and lower percentage T3U than sheep. The INS to GLN ratio (I/G), was also greater (P < 0.05) in goats. SF increased (P < 0.05) GLU and NEFA and decreased (P < 0.01) PUN. INS tended to decrease and GLN to increase in response to SF, resulting in a lower (P < 0.05) I/G. SF increased (P < 0.05) T4 concentrations and lowered (P < 0.05) the percentage T3U. Protein supplementation increased (P < 0.01) PUN concentrations without affecting plasma concentrations of GLU and NEFA. Plasma concentrations of INS and GLN did not change in response to protein supplementation, while metabolite and hormonal changes were minimal, but SF administration resulted in major changes in blood metabolite and hormone profiles.

Original languageEnglish (US)
Pages (from-to)73-84
Number of pages12
JournalSmall Ruminant Research
Volume6
Issue number1-2
DOIs
StatePublished - Oct 1991
Externally publishedYes

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protein supplements
Dietary Fiber
Goats
glucagon
Sheep
Glucagon
insulin
Nonesterified Fatty Acids
goats
Insulin
free fatty acids
sheep
Glucose
glucose
L-thyroxine
triiodothyronine
Proteins
parasympathomimetics
Barbados Blackbelly
Parasympathomimetics

ASJC Scopus subject areas

  • Food Animals
  • Animal Science and Zoology

Cite this

Metabolic responses to protein supplementation and slaframine in goats and sheep fed roughage. / Gaskins, H. R.; Croom, W. J.; Fernandez, J. M.; van Eys, J. E.; Hagler, W. M.; Johnson, W. L.

In: Small Ruminant Research, Vol. 6, No. 1-2, 10.1991, p. 73-84.

Research output: Contribution to journalArticle

Gaskins, H. R. ; Croom, W. J. ; Fernandez, J. M. ; van Eys, J. E. ; Hagler, W. M. ; Johnson, W. L. / Metabolic responses to protein supplementation and slaframine in goats and sheep fed roughage. In: Small Ruminant Research. 1991 ; Vol. 6, No. 1-2. pp. 73-84.
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