Metabolic enzymes as targets for 14-3-3 proteins

Steven C. Huber, Carol MacKintosh, Werner M. Kaiser

Research output: Contribution to journalReview article

Abstract

The 14-3-3 proteins are binding proteins that have been shown to interact with a wide array of enzymes involved in primary biosynthetic and energy metabolism in plants. In most cases, the significance of binding of the 14-3-3 protein is not known. However, most of the interactions are phosphorylation-dependent and most of the known binding partners are found in the cytosol, while some may also be localized to plastids and mitochondria. In this review, we examine the factors that may regulate the binding of 14-3-3s to their target proteins, and discuss their possible roles in the regulation of the activity and proteolytic degradation of enzymes involved in primary carbon and nitrogen metabolism.

Original languageEnglish (US)
Pages (from-to)1053-1063
Number of pages11
JournalPlant Molecular Biology
Volume50
Issue number6
DOIs
StatePublished - Dec 2002

Keywords

  • 14-3-3-affinity chromatography
  • Divalent cations
  • Glutamine synthetase
  • NADH:nitrate reductase
  • Polyamines
  • Proteolytic degradation
  • Sucrose-phosphate synthase

ASJC Scopus subject areas

  • Agronomy and Crop Science
  • Genetics
  • Plant Science

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  • Cite this

    Huber, S. C., MacKintosh, C., & Kaiser, W. M. (2002). Metabolic enzymes as targets for 14-3-3 proteins. Plant Molecular Biology, 50(6), 1053-1063. https://doi.org/10.1023/A:1021284002779