Metabolic Effects of Obesity and Its Interaction with Endocrine Diseases

Melissa Clark, Margarethe Hoenig

Research output: Contribution to journalReview articlepeer-review


Obesity in pet dogs and cats is a significant problem in developed countries, and seems to be increasing in prevalence. Excess body fat has adverse metabolic consequences, including insulin resistance, altered adipokine secretion, changes in metabolic rate, abnormal lipid metabolism, and fat accumulation in visceral organs. Obese cats are predisposed to endocrine and metabolic disorders such as diabetes and hepatic lipidosis. A connection likely also exists between obesity and diabetes mellitus in dogs. No system has been developed to identify obese pets at greatest risk for development of obesity-associated metabolic diseases, and further study in this area is needed.

Original languageEnglish (US)
Pages (from-to)797-815
Number of pages19
JournalVeterinary Clinics of North America - Small Animal Practice
Issue number5
StatePublished - Sep 1 2016


  • Adipocytokines
  • Canine
  • Diabetes
  • Dyslipidemia
  • Feline
  • Hepatic lipidosis
  • Insulin resistance
  • Obesity

ASJC Scopus subject areas

  • Small Animals


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