Mesoporous ZnS nanorattles: Programmed size selected access to encapsulated enzymes

Dara Van Gough, Alejandro Wolosiuk, Paul V. Braun

Research output: Contribution to journalArticlepeer-review


A size selective nanorattle was formed by encapsulating soybean peroxidase (SBP) within a ZnS mesoporous hollow sphere. Once encapsulated within the mesoporous hollow sphere, the SBP remained active against molecules smaller than the 3 nm diameter of the mesopores in the shell wall, while molecules larger than the mesopores, which could not pass into the hollow sphere, did not interact with the SBP. Specifically, encapsulated SBP catalyzed the oxidation of Amplex Ultra-Red, a small fluorogen, in the presence of hydrogen peroxide, encapsulated SBP was deactivated by sodium azide, and no reaction was observed between encapsulated SBP and a greater than 3 nm diameter protease.

Original languageEnglish (US)
Pages (from-to)1994-1998
Number of pages5
JournalNano letters
Issue number5
StatePublished - May 13 2009

ASJC Scopus subject areas

  • Bioengineering
  • General Chemistry
  • General Materials Science
  • Condensed Matter Physics
  • Mechanical Engineering


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