TY - JOUR
T1 - Mesenchymal Stem Cells
T2 - Characteristics, Sources, and Mechanisms of Action
AU - Stewart, Matthew C.
AU - Stewart, Allison A.
PY - 2011/8
Y1 - 2011/8
N2 - This article provides an overview of mesenchymal stem cell (MSC) biology. In the first section, the characteristics that are routinely used to define MSCs-adherence, proliferation, multi-lineage potential, and "cluster of differentiation" marker profiles-are discussed. In the second section, the major tissues and body fluids that are used as sources for equine MSCs are presented, along with the comparative biologic activities of MSCs from specific locations. Finally, the current understanding of the mechanisms by which MSCs influence repair and regeneration are discussed, with an emphasis on the clinical importance of MSC trophic activities.
AB - This article provides an overview of mesenchymal stem cell (MSC) biology. In the first section, the characteristics that are routinely used to define MSCs-adherence, proliferation, multi-lineage potential, and "cluster of differentiation" marker profiles-are discussed. In the second section, the major tissues and body fluids that are used as sources for equine MSCs are presented, along with the comparative biologic activities of MSCs from specific locations. Finally, the current understanding of the mechanisms by which MSCs influence repair and regeneration are discussed, with an emphasis on the clinical importance of MSC trophic activities.
KW - Chondrogenesis
KW - Differentiation
KW - Mesenchymal stem cell
KW - Osteogenesis
UR - http://www.scopus.com/inward/record.url?scp=80052101258&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80052101258&partnerID=8YFLogxK
U2 - 10.1016/j.cveq.2011.06.004
DO - 10.1016/j.cveq.2011.06.004
M3 - Review article
C2 - 21872757
AN - SCOPUS:80052101258
SN - 0749-0739
VL - 27
SP - 243
EP - 261
JO - Veterinary Clinics of North America - Equine Practice
JF - Veterinary Clinics of North America - Equine Practice
IS - 2
ER -