Merely two mutations switch a DNA-hydrolyzing deoxyribozyme from heterobimetallic (Zn2+/Mn2+) to monometallic (Zn 2+-only) behavior

Ying Xiao, Emily C. Allen, Scott K Silverman

Research output: Contribution to journalArticle

Abstract

A deoxyribozyme that hydrolyzes DNA phosphodiester linkages with a requirement for both Zn2+ and Mn2+ is switched by only two nucleotide mutations to require Zn2+ alone, demonstrating that DNA-catalyzed DNA hydrolysis can be achieved using only one metal ion cofactor.

Original languageEnglish (US)
Pages (from-to)1749-1751
Number of pages3
JournalChemical Communications
Volume47
Issue number6
DOIs
StatePublished - Feb 14 2011

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Catalytic DNA
DNA
Switches
Nucleotides
Metal ions
Hydrolysis

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Cite this

Merely two mutations switch a DNA-hydrolyzing deoxyribozyme from heterobimetallic (Zn2+/Mn2+) to monometallic (Zn 2+-only) behavior. / Xiao, Ying; Allen, Emily C.; Silverman, Scott K.

In: Chemical Communications, Vol. 47, No. 6, 14.02.2011, p. 1749-1751.

Research output: Contribution to journalArticle

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