TY - GEN
T1 - MEMS Based sensors for the study of indentation response of single cells
AU - Yang, Shengyuan
AU - Saif, M Taher A
PY - 2006
Y1 - 2006
N2 - This paper presents bioMEMS force sensors, consisting of a probe and flexible beams, to study mechanobiological response of single living cells subjected to mechanical injury. Mechanical injuries are simulated by the application of large indentation on the cells by the sensor probe. The green fluorescent protein (GFP) technique is used to visualize the evolution of the actin network in the cells. The lateral indentation force response measurement capability of the sensors is shown. Two new types of remodeling, large buckling of stress fibers and actin agglomeration, in the actin network in a cell due to mechanical stimuli are reported.
AB - This paper presents bioMEMS force sensors, consisting of a probe and flexible beams, to study mechanobiological response of single living cells subjected to mechanical injury. Mechanical injuries are simulated by the application of large indentation on the cells by the sensor probe. The green fluorescent protein (GFP) technique is used to visualize the evolution of the actin network in the cells. The lateral indentation force response measurement capability of the sensors is shown. Two new types of remodeling, large buckling of stress fibers and actin agglomeration, in the actin network in a cell due to mechanical stimuli are reported.
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M3 - Conference contribution
AN - SCOPUS:33750100945
SN - 0780394755
SN - 9780780394759
T3 - Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
SP - 20
EP - 23
BT - 19th IEEE International Conference on Micro Electro Mechanical Systems
T2 - 19th IEEE International Conference on Micro Electro Mechanical Systems
Y2 - 22 January 2006 through 26 January 2006
ER -