MEMS Based sensors for the study of indentation response of single cells

Shengyuan Yang, M Taher A Saif

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This paper presents bioMEMS force sensors, consisting of a probe and flexible beams, to study mechanobiological response of single living cells subjected to mechanical injury. Mechanical injuries are simulated by the application of large indentation on the cells by the sensor probe. The green fluorescent protein (GFP) technique is used to visualize the evolution of the actin network in the cells. The lateral indentation force response measurement capability of the sensors is shown. Two new types of remodeling, large buckling of stress fibers and actin agglomeration, in the actin network in a cell due to mechanical stimuli are reported.

Original languageEnglish (US)
Title of host publication19th IEEE International Conference on Micro Electro Mechanical Systems
Pages20-23
Number of pages4
Volume2006
StatePublished - 2006
Event19th IEEE International Conference on Micro Electro Mechanical Systems - Istanbul, Turkey
Duration: Jan 22 2006Jan 26 2006

Other

Other19th IEEE International Conference on Micro Electro Mechanical Systems
CountryTurkey
CityIstanbul
Period1/22/061/26/06

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ASJC Scopus subject areas

  • Mechanical Engineering
  • Electrical and Electronic Engineering
  • Control and Systems Engineering

Cite this

Yang, S., & Saif, M. T. A. (2006). MEMS Based sensors for the study of indentation response of single cells. In 19th IEEE International Conference on Micro Electro Mechanical Systems (Vol. 2006, pp. 20-23). [1627726]