Memory and amnesia: resistance to disruption develops for years after learning

Larry R. Squire, Neal Cohen

Research output: Contribution to journalArticle

Abstract

Psychiatric patients were asked to recall as much as possible about former television programs that broadcast for only one season (1967-1974). After five prescribed electroconvulsive treatments, recall was markedly impaired for events that occurred 1 to 2 years before treatment and not affected for events that occurred prior to that time. A quantitative and qualitative analysis of the facts recalled from each time period permitted consideration of several possible explanations of this temporally graded amnesia. The data strongly support the conclusion that the neural substrate of long-term memory changes for years after learning and that resistance to amnesia develops as a consequence of these changes.

Original languageEnglish (US)
Pages (from-to)115-125
Number of pages11
JournalBehavioral and Neural Biology
Volume25
Issue number1
DOIs
StatePublished - Jan 1979
Externally publishedYes

Fingerprint

Amnesia
Learning
Long-Term Memory
Television
Psychiatry
Therapeutics

ASJC Scopus subject areas

  • Physiology

Cite this

Memory and amnesia : resistance to disruption develops for years after learning. / Squire, Larry R.; Cohen, Neal.

In: Behavioral and Neural Biology, Vol. 25, No. 1, 01.1979, p. 115-125.

Research output: Contribution to journalArticle

@article{339634b6fd4745689a94b88e220e93e3,
title = "Memory and amnesia: resistance to disruption develops for years after learning",
abstract = "Psychiatric patients were asked to recall as much as possible about former television programs that broadcast for only one season (1967-1974). After five prescribed electroconvulsive treatments, recall was markedly impaired for events that occurred 1 to 2 years before treatment and not affected for events that occurred prior to that time. A quantitative and qualitative analysis of the facts recalled from each time period permitted consideration of several possible explanations of this temporally graded amnesia. The data strongly support the conclusion that the neural substrate of long-term memory changes for years after learning and that resistance to amnesia develops as a consequence of these changes.",
author = "Squire, {Larry R.} and Neal Cohen",
year = "1979",
month = "1",
doi = "10.1016/S0163-1047(79)90841-0",
language = "English (US)",
volume = "25",
pages = "115--125",
journal = "Neurobiology of Learning and Memory",
issn = "1074-7427",
publisher = "Academic Press Inc.",
number = "1",

}

TY - JOUR

T1 - Memory and amnesia

T2 - resistance to disruption develops for years after learning

AU - Squire, Larry R.

AU - Cohen, Neal

PY - 1979/1

Y1 - 1979/1

N2 - Psychiatric patients were asked to recall as much as possible about former television programs that broadcast for only one season (1967-1974). After five prescribed electroconvulsive treatments, recall was markedly impaired for events that occurred 1 to 2 years before treatment and not affected for events that occurred prior to that time. A quantitative and qualitative analysis of the facts recalled from each time period permitted consideration of several possible explanations of this temporally graded amnesia. The data strongly support the conclusion that the neural substrate of long-term memory changes for years after learning and that resistance to amnesia develops as a consequence of these changes.

AB - Psychiatric patients were asked to recall as much as possible about former television programs that broadcast for only one season (1967-1974). After five prescribed electroconvulsive treatments, recall was markedly impaired for events that occurred 1 to 2 years before treatment and not affected for events that occurred prior to that time. A quantitative and qualitative analysis of the facts recalled from each time period permitted consideration of several possible explanations of this temporally graded amnesia. The data strongly support the conclusion that the neural substrate of long-term memory changes for years after learning and that resistance to amnesia develops as a consequence of these changes.

UR - http://www.scopus.com/inward/record.url?scp=0018748251&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018748251&partnerID=8YFLogxK

U2 - 10.1016/S0163-1047(79)90841-0

DO - 10.1016/S0163-1047(79)90841-0

M3 - Article

C2 - 454335

AN - SCOPUS:0018748251

VL - 25

SP - 115

EP - 125

JO - Neurobiology of Learning and Memory

JF - Neurobiology of Learning and Memory

SN - 1074-7427

IS - 1

ER -