Membrane-actin interactions in morphogenesis: Lessons learned from Drosophila cellularization

Anna Marie Sokac, Natalie Biel, Stefano De Renzis

Research output: Contribution to journalReview articlepeer-review


During morphogenesis, changes in the shapes of individual cells are harnessed to mold an entire tissue. These changes in cell shapes require the coupled remodeling of the plasma membrane and underlying actin cytoskeleton. In this review, we highlight cellularization of the Drosophila embryo as a model system to uncover principles of how membrane and actin dynamics are co-regulated in space and time to drive morphogenesis.

Original languageEnglish (US)
Pages (from-to)107-122
Number of pages16
JournalSeminars in Cell and Developmental Biology
StatePublished - Jan 15 2023


  • Actin
  • Cortical compartments
  • Cytokinesis
  • Endocytosis
  • Exocytosis
  • Membrane reservoir
  • Membrane trafficking
  • Myosin-2
  • Phosphoinositides

ASJC Scopus subject areas

  • Cell Biology
  • Developmental Biology


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