Meeting Report: Spontaneous Lesions and Diseases in Wild, Captive-Bred, and Zoo-Housed Nonhuman Primates and in Nonhuman Primate Species Used in Drug Safety Studies

V. G. Sasseville, K. G. Mansfield, J. L. Mankowski, C. Tremblay, K. A. Terio, K. Mätz-Rensing, E. Gruber-Dujardin, M. A. Delaney, L. D. Schmidt, D. Liu, J. E. Markovits, M. Owston, C. Harbison, S. Shanmukhappa, A. D. Miller, S. Kaliyaperumal, B. T. Assaf, L. Kattenhorn, S. Cummings Macri, H. A. SimmonsA. Baldessari, P. Sharma, C. Courtney, A. Bradley, J. M. Cline, J. F. Reindel, D. L. Hutto, R. J. Montali, L. J. Lowenstine

Research output: Contribution to journalArticlepeer-review


The combination of loss of habitat, human population encroachment, and increased demand of select nonhuman primates for biomedical research has significantly affected populations. There remains a need for knowledge and expertise in understanding background findings as related to the age, source, strain, and disease status of nonhuman primates. In particular, for safety/biomedical studies, a broader understanding and documentation of lesions would help clarify background from drug-related findings. A workshop and a minisymposium on spontaneous lesions and diseases in nonhuman primates were sponsored by the concurrent Annual Meetings of the American College of Veterinary Pathologists and the American Society for Veterinary Clinical Pathology held December 3-4, 2011, in Nashville, Tennessee. The first session had presentations from Drs Lowenstine and Montali, pathologists with extensive experience in wild and zoo populations of nonhuman primates, which was followed by presentations of 20 unique case reports of rare or newly observed spontaneous lesions in nonhuman primates (see online files for access to digital whole-slide images corresponding to each case report at The minisymposium was composed of 5 nonhuman-primate researchers (Drs Bradley, Cline, Sasseville, Miller, Hutto) who concentrated on background and spontaneous lesions in nonhuman primates used in drug safety studies. Cynomolgus and rhesus macaques were emphasized, with some material presented on common marmosets. Congenital, acquired, inflammatory, and neoplastic changes were highlighed with a focus on clinical, macroscopic, and histopathologic findings that could confound the interpretation of drug safety studies.

Original languageEnglish (US)
Pages (from-to)1057-1069
Number of pages13
JournalVeterinary pathology
Issue number6
StatePublished - Nov 2012
Externally publishedYes


  • Aotus trivirgatus
  • Armillifer agkistrodontis
  • Aspergillus fumigatus
  • Brunner's gland hyperplasia
  • Callithrix jacchus
  • Cebussp
  • Cercocebus torquatus torquatus
  • Cercopithecus nictitans
  • Chlorocebus aethiops
  • Chromobacterium violaceum
  • Cryptosporidium muris-like
  • Gorilla beringei beringei
  • Helicobacter heilmannii-like
  • Macaca fascicularis
  • Macaca mulatta
  • Macaca nemestrina
  • Mandrillus sphinx
  • Pan paniscus
  • Pan troglodytes
  • Papio cynocephalus
  • Plasmodium inui
  • Pongo pygmaeus
  • Saguinus oedipus
  • amyloidosis
  • bonobo
  • cardiomyopathy
  • chimpanzee
  • colitis
  • cytomegalovirus
  • diabetic nephropathy
  • encephalitis
  • enteritis
  • ependymoblastoma
  • epitheliotropic lymphoma
  • gorilla
  • hyperadrenocorticism
  • intestinal carcinoma
  • lymphocytic choriomeningitis virus
  • macaque
  • marmoset
  • metapneumovirus
  • multiple myeloma
  • oncocytic adrenocortical carcinoma
  • orangutan
  • ovarian teratoma
  • papillomavirus
  • pheochromocytoma
  • pneumonia
  • simian human immunodeficiency virus
  • simian immunodeficiency virus
  • squamous cell carcinoma
  • tamarin

ASJC Scopus subject areas

  • General Veterinary


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