Medication use, tamoxifen (TAM), and TAM metabolite concentrations in women with breast cancer

Lisa Gallicchio; Katherine Tkaczuk; Gwyn Lord; Malcolm Danton; Lynn M. Lewis; Chang K. Lim; Jodi A. Flaws

doi:10.1016/j.canlet.2004.04.001

Medication use, tamoxifen (TAM), and TAM metabolite concentrations in women with breast cancer

Lisa Gallicchio, Katherine Tkaczuk, Gwyn Lord, Malcolm Danton, Lynn M. Lewis, Chang K. Lim, Jodi A. Flaws

Research output: Contribution to journal › Article › peer-review

Abstract

Tamoxifen (TAM) is commonly used as an adjuvant treatment for breast cancer. Although patients taking TAM are often taking medications for comorbidities, data regarding the interaction of TAM with other medications are limited. Thus, this study was carried out to determine whether medications co-prescribed with TAM significantly influence the plasma concentrations of TAM and its metabolites (N-desmethyltamoxifen; N-DMT and 4-hydroxytamoxifen; 4-OHT) in 98 women diagnosed with breast cancer. Participants taking diuretics had significantly higher plasma concentrations of TAM and N-DMT than participants not taking a diuretic. Arthritis/pain medication intake was negatively associated with plasma TAM concentrations. Chemotherapeutic agents, allergy drugs, anti-depressants, and diabetes medications did not significantly alter plasma TAM or metabolite concentrations. This suggests that diuretic or an arthritis/pain medication may affect TAM metabolism.

Original language	English (US)
Pages (from-to)	57-67
Number of pages	11
Journal	Cancer Letters
Volume	211
Issue number	1
DOIs	https://doi.org/10.1016/j.canlet.2004.04.001
State	Published - Jul 28 2004
Externally published	Yes

Keywords

Breast cancer
Metabolism
Tamoxifen

ASJC Scopus subject areas

Oncology
Cancer Research

Online availability

10.1016/j.canlet.2004.04.001

Library availability

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title = "Medication use, tamoxifen (TAM), and TAM metabolite concentrations in women with breast cancer",

abstract = "Tamoxifen (TAM) is commonly used as an adjuvant treatment for breast cancer. Although patients taking TAM are often taking medications for comorbidities, data regarding the interaction of TAM with other medications are limited. Thus, this study was carried out to determine whether medications co-prescribed with TAM significantly influence the plasma concentrations of TAM and its metabolites (N-desmethyltamoxifen; N-DMT and 4-hydroxytamoxifen; 4-OHT) in 98 women diagnosed with breast cancer. Participants taking diuretics had significantly higher plasma concentrations of TAM and N-DMT than participants not taking a diuretic. Arthritis/pain medication intake was negatively associated with plasma TAM concentrations. Chemotherapeutic agents, allergy drugs, anti-depressants, and diabetes medications did not significantly alter plasma TAM or metabolite concentrations. This suggests that diuretic or an arthritis/pain medication may affect TAM metabolism.",

keywords = "Breast cancer, Metabolism, Tamoxifen",

author = "Lisa Gallicchio and Katherine Tkaczuk and Gwyn Lord and Malcolm Danton and Lewis, {Lynn M.} and Lim, {Chang K.} and Flaws, {Jodi A.}",

note = "Funding Information: This study was supported by DOD Grant DAMD17-00-1-0321, NIH T32 ES0726313, and the University of Maryland, Maryland Statewide Health Network through the Maryland Cigarette Restitution Funds.",

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doi = "10.1016/j.canlet.2004.04.001",

language = "English (US)",

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AU - Gallicchio, Lisa

AU - Tkaczuk, Katherine

AU - Lord, Gwyn

AU - Danton, Malcolm

AU - Lewis, Lynn M.

AU - Lim, Chang K.

AU - Flaws, Jodi A.

N1 - Funding Information: This study was supported by DOD Grant DAMD17-00-1-0321, NIH T32 ES0726313, and the University of Maryland, Maryland Statewide Health Network through the Maryland Cigarette Restitution Funds.

PY - 2004/7/28

Y1 - 2004/7/28

N2 - Tamoxifen (TAM) is commonly used as an adjuvant treatment for breast cancer. Although patients taking TAM are often taking medications for comorbidities, data regarding the interaction of TAM with other medications are limited. Thus, this study was carried out to determine whether medications co-prescribed with TAM significantly influence the plasma concentrations of TAM and its metabolites (N-desmethyltamoxifen; N-DMT and 4-hydroxytamoxifen; 4-OHT) in 98 women diagnosed with breast cancer. Participants taking diuretics had significantly higher plasma concentrations of TAM and N-DMT than participants not taking a diuretic. Arthritis/pain medication intake was negatively associated with plasma TAM concentrations. Chemotherapeutic agents, allergy drugs, anti-depressants, and diabetes medications did not significantly alter plasma TAM or metabolite concentrations. This suggests that diuretic or an arthritis/pain medication may affect TAM metabolism.

AB - Tamoxifen (TAM) is commonly used as an adjuvant treatment for breast cancer. Although patients taking TAM are often taking medications for comorbidities, data regarding the interaction of TAM with other medications are limited. Thus, this study was carried out to determine whether medications co-prescribed with TAM significantly influence the plasma concentrations of TAM and its metabolites (N-desmethyltamoxifen; N-DMT and 4-hydroxytamoxifen; 4-OHT) in 98 women diagnosed with breast cancer. Participants taking diuretics had significantly higher plasma concentrations of TAM and N-DMT than participants not taking a diuretic. Arthritis/pain medication intake was negatively associated with plasma TAM concentrations. Chemotherapeutic agents, allergy drugs, anti-depressants, and diabetes medications did not significantly alter plasma TAM or metabolite concentrations. This suggests that diuretic or an arthritis/pain medication may affect TAM metabolism.

KW - Breast cancer

KW - Metabolism

KW - Tamoxifen

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Medication use, tamoxifen (TAM), and TAM metabolite concentrations in women with breast cancer

Abstract

Keywords

ASJC Scopus subject areas

Online availability

Library availability

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