Mechanotransduction at focal adhesions: From physiology to cancer development

Jihye Seong, Ning Wang, Yingxiao Wang

Research output: Contribution to journalArticle

Abstract

Living cells are continuously exposed to mechanical cues, and can translate these signals into biochemical information (e.g. mechanotransduction). This process is crucial in many normal cellular functions, e.g. cell adhesion, migration, proliferation, and survival, as well as the progression of diseases such as cancer. Focal adhesions are the major sites of interactions between extracellular mechanical environments and intracellular biochemical signalling molecules/cytoskeleton, and hence focal adhesion proteins have been suggested to play important roles in mechanotransduction. Here, we overview the current molecular understanding in mechanotransduction occurring at focal adhesions. We also introduce recent studies on how extracellular matrix and mechanical microenvironments contribute to the development of cancer.

Original languageEnglish (US)
Pages (from-to)597-604
Number of pages8
JournalJournal of Cellular and Molecular Medicine
Volume17
Issue number5
DOIs
StatePublished - May 2013

Keywords

  • Cancer
  • Extracellular Matrix
  • Focal Adhesions
  • Integrin
  • Invadopodia
  • Mechanotransduction

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Medicine

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