Mechanotransduction at a distance: Mechanically coupling the extracellular matrix with the nucleus

Ning Wang, Jessica D. Tytell, Donald E. Ingber

Research output: Contribution to journalComment/debatepeer-review

Abstract

Research in cellular mechanotransduction often focuses on how extracellular physical forces are converted into chemical signals at the cell surface. However, mechanical forces that are exerted on surface-adhesion receptors, such as integrins and cadherins, are also channelled along cytoskeletal filaments and concentrated at distant sites in the cytoplasm and nucleus. Here, we explore the molecular mechanisms by which forces might act at a distance to induce mechanochemical conversion in the nucleus and alter gene activities.

Original languageEnglish (US)
Pages (from-to)75-82
Number of pages8
JournalNature Reviews Molecular Cell Biology
Volume10
Issue number1
DOIs
StatePublished - Jan 2009

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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