Mechanochemical functionalization of disulfide linked hydrogels

Junmin Lee, Meredith N. Silberstein, Amr A. Abdeen, Sang Yup Kim, Kristopher A. Kilian

Research output: Contribution to journalArticlepeer-review


Poly(ethylene glycol) hydrogels with disulfide linkages are functionalized through applied force. Compression or tension induces bond rupture at the relatively weak disulfide linkages, which will subsequently react through Michael-type addition with an acceptor molecule within the gel. We demonstrate the utility of this approach by patterning cell adhesion proteins through compression of a lithographically structured stamp, where cells predominately adhere to the compressed regions.

Original languageEnglish (US)
Pages (from-to)447-451
Number of pages5
JournalMaterials Horizons
Issue number5
StatePublished - Sep 2016

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Process Chemistry and Technology
  • Electrical and Electronic Engineering


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