Mechanochemical functionalization of disulfide linked hydrogels

Junmin Lee; Meredith N. Silberstein; Amr A. Abdeen; Sang Yup Kim; Kristopher A. Kilian

doi:10.1039/c6mh00091f

Mechanochemical functionalization of disulfide linked hydrogels

Junmin Lee, Meredith N. Silberstein, Amr A. Abdeen, Sang Yup Kim, Kristopher A. Kilian

Research output: Contribution to journal › Article › peer-review

Abstract

Poly(ethylene glycol) hydrogels with disulfide linkages are functionalized through applied force. Compression or tension induces bond rupture at the relatively weak disulfide linkages, which will subsequently react through Michael-type addition with an acceptor molecule within the gel. We demonstrate the utility of this approach by patterning cell adhesion proteins through compression of a lithographically structured stamp, where cells predominately adhere to the compressed regions.

Original language	English (US)
Pages (from-to)	447-451
Number of pages	5
Journal	Materials Horizons
Volume	3
Issue number	5
DOIs	https://doi.org/10.1039/c6mh00091f
State	Published - Sep 2016

ASJC Scopus subject areas

Materials Science(all)
Mechanics of Materials
Process Chemistry and Technology
Electrical and Electronic Engineering

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10.1039/c6mh00091f

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abstract = "Poly(ethylene glycol) hydrogels with disulfide linkages are functionalized through applied force. Compression or tension induces bond rupture at the relatively weak disulfide linkages, which will subsequently react through Michael-type addition with an acceptor molecule within the gel. We demonstrate the utility of this approach by patterning cell adhesion proteins through compression of a lithographically structured stamp, where cells predominately adhere to the compressed regions.",

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AU - Kilian, Kristopher A.

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