Mechanochemical functionalization of disulfide linked hydrogels

Junmin Lee, Meredith N. Silberstein, Amr A. Abdeen, Sang Yup Kim, Kristopher A. Kilian

Research output: Contribution to journalArticlepeer-review

Abstract

Poly(ethylene glycol) hydrogels with disulfide linkages are functionalized through applied force. Compression or tension induces bond rupture at the relatively weak disulfide linkages, which will subsequently react through Michael-type addition with an acceptor molecule within the gel. We demonstrate the utility of this approach by patterning cell adhesion proteins through compression of a lithographically structured stamp, where cells predominately adhere to the compressed regions.

Original languageEnglish (US)
Pages (from-to)447-451
Number of pages5
JournalMaterials Horizons
Volume3
Issue number5
DOIs
StatePublished - Sep 2016

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Process Chemistry and Technology
  • Electrical and Electronic Engineering

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