TY - CHAP
T1 - Mechanobiology of Collective Cell Migration in 3D Microenvironments
AU - Hruska, Alex M.
AU - Yang, Haiqian
AU - Leggett, Susan E.
AU - Guo, Ming
AU - Wong, Ian Y.
N1 - Funding Information:
Acknowledgments We apologize to authors whose work could not be included due to space constraints. This work was supported by the National Institute of General Medical Sciences (R01GM140108, P20GM109035).
Publisher Copyright:
© 2023, The Author(s), under exclusive license to Springer Nature Switzerland AG.
PY - 2023
Y1 - 2023
N2 - Tumor cells invade individually or in groups, mediated by mechanical interactions between cells and their surrounding matrix. These multicellular dynamics are reminiscent of leader-follower coordination and epithelial-mesenchymal transitions (EMT) in tissue development, which may occur via dysregulation of associated molecular or physical mechanisms. However, it remains challenging to elucidate such phenotypic heterogeneity and plasticity without precision measurements of single-cell behavior. The convergence of technological developments in live cell imaging, biophysical measurements, and 3D biomaterials is highly promising to reveal how tumor cells cooperate in aberrant microenvironments. Here, we highlight new results in collective migration from the perspective of cancer biology and bioengineering. First, we review the biology of collective cell migration. Next, we consider physics-inspired analyses based on order parameters and phase transitions. Further, we examine the interplay of metabolism and phenotypic heterogeneity in collective migration. We then review the extracellular matrix and new modalities for mechanical characterization of 3D biomaterials. We also explore epithelial-mesenchymal plasticity and implications for tumor progression. Finally, we speculate on future directions for integrating mechanobiology and cancer cell biology to elucidate collective migration.
AB - Tumor cells invade individually or in groups, mediated by mechanical interactions between cells and their surrounding matrix. These multicellular dynamics are reminiscent of leader-follower coordination and epithelial-mesenchymal transitions (EMT) in tissue development, which may occur via dysregulation of associated molecular or physical mechanisms. However, it remains challenging to elucidate such phenotypic heterogeneity and plasticity without precision measurements of single-cell behavior. The convergence of technological developments in live cell imaging, biophysical measurements, and 3D biomaterials is highly promising to reveal how tumor cells cooperate in aberrant microenvironments. Here, we highlight new results in collective migration from the perspective of cancer biology and bioengineering. First, we review the biology of collective cell migration. Next, we consider physics-inspired analyses based on order parameters and phase transitions. Further, we examine the interplay of metabolism and phenotypic heterogeneity in collective migration. We then review the extracellular matrix and new modalities for mechanical characterization of 3D biomaterials. We also explore epithelial-mesenchymal plasticity and implications for tumor progression. Finally, we speculate on future directions for integrating mechanobiology and cancer cell biology to elucidate collective migration.
KW - Biomaterials
KW - Epithelial-mesenchymal transition
KW - Extracellular matrix
KW - Metabolic heterogeneity
KW - Order parameter
KW - Traction force microscopy
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U2 - 10.1007/978-3-031-22802-5_1
DO - 10.1007/978-3-031-22802-5_1
M3 - Chapter
AN - SCOPUS:85153199433
T3 - Current Cancer Research
SP - 1
EP - 32
BT - Current Cancer Research
PB - Springer
ER -