Mechanistic studies on the conversion of arylamines into arylnitro compounds by aminopyrrolnitrin oxygenase: identification of intermediates and kinetic studies

Jungkul Lee, Huimin Zhao

Research output: Contribution to journalArticle

Abstract

(Chemical Equation Presented) Rieske business! The Rieske N-oxygenase, aminopyrrolnitrin oxygenase (PrnD), catalyzes the unusual oxidation of arylamines to arylnitro compounds. Kinetic analysis has confirmed that PrnD catalyzes the conversion of the substrate pABA (4-aminobenzylamine) through at least three consecutive reactions: two monooxygenation steps and one dehydrogenation step (see scheme).

Original languageEnglish (US)
Pages (from-to)622-625
Number of pages4
JournalAngewandte Chemie - International Edition
Volume45
Issue number4
DOIs
StatePublished - Jan 16 2006

Keywords

  • Amines
  • Enzyme catalysis
  • Oxygenation
  • Reaction mechanisms
  • Reactive intermediates

ASJC Scopus subject areas

  • Chemistry(all)

Fingerprint Dive into the research topics of 'Mechanistic studies on the conversion of arylamines into arylnitro compounds by aminopyrrolnitrin oxygenase: identification of intermediates and kinetic studies'. Together they form a unique fingerprint.

  • Cite this