Mechanisms of enteral nutrient-enhanced intestinal adaptation

Kelly A. Tappenden

Research output: Contribution to journalArticlepeer-review


The role of enteral nutrients in maintaining small intestinal structure and function is well established. Evidence that enteral nutrients induce intestinal adaptation include the structural and functional gradient along the length of the healthy intestine, the atrophy and functional compromise induced by fasting and parenteral nutrition, and the enhanced adaptive capacity of the distal intestine following partial enterectomy. Key mechanisms contributing to enteral nutrient-induced intestinal adaptation include nonspecific luminal stimulation and that provided by specific nutrients, "functional workload" induced by polymeric nutrients, potential stimulation of pancreaticobiliary secretions, secretion of humoral mediators, and induction of intestinal hyperemia.

Original languageEnglish (US)
Pages (from-to)S93-S99
Issue number2 SUPPL.
StatePublished - Feb 2006

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


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