Mechanisms of actin disassembly

Research output: Contribution to journalReview article

Abstract

The actin cytoskeleton is constantly assembling and disassembling. Cells harness the energy of these turnover dynamics to drive cell motility and organize cytoplasm. Although much is known about how cells control actin polymerization, we do not understand how actin filaments depolymerize inside cells. I briefly describe how the combination of imaging actin filament dynamics in cells and using in vitro biochemistry progressively altered our views of actin depolymerization. I describe why I do not think that the prevailing model of actin filament turnover-cofilin-mediated actin filament severing-can account for actin filament disassembly detected in cells. Finally, I speculate that cells might be able to tune the mechanism of actin depolymerization to meet physiological demands and selectively control the stabilities of different actin arrays.

Original languageEnglish (US)
Pages (from-to)2299-2302
Number of pages4
JournalMolecular biology of the cell
Volume24
Issue number15
DOIs
StatePublished - Aug 1 2013

Fingerprint

Actin Cytoskeleton
Actins
Actin Depolymerizing Factors
Polymerization
Biochemistry
Cell Movement
Cytoplasm

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Cite this

Mechanisms of actin disassembly. / Brieher, William.

In: Molecular biology of the cell, Vol. 24, No. 15, 01.08.2013, p. 2299-2302.

Research output: Contribution to journalReview article

@article{8a0fab221fba44ff97568420cf99cd5c,
title = "Mechanisms of actin disassembly",
abstract = "The actin cytoskeleton is constantly assembling and disassembling. Cells harness the energy of these turnover dynamics to drive cell motility and organize cytoplasm. Although much is known about how cells control actin polymerization, we do not understand how actin filaments depolymerize inside cells. I briefly describe how the combination of imaging actin filament dynamics in cells and using in vitro biochemistry progressively altered our views of actin depolymerization. I describe why I do not think that the prevailing model of actin filament turnover-cofilin-mediated actin filament severing-can account for actin filament disassembly detected in cells. Finally, I speculate that cells might be able to tune the mechanism of actin depolymerization to meet physiological demands and selectively control the stabilities of different actin arrays.",
author = "William Brieher",
year = "2013",
month = "8",
day = "1",
doi = "10.1091/mbc.E12-09-0694",
language = "English (US)",
volume = "24",
pages = "2299--2302",
journal = "Molecular Biology of the Cell",
issn = "1059-1524",
publisher = "American Society for Cell Biology",
number = "15",

}

TY - JOUR

T1 - Mechanisms of actin disassembly

AU - Brieher, William

PY - 2013/8/1

Y1 - 2013/8/1

N2 - The actin cytoskeleton is constantly assembling and disassembling. Cells harness the energy of these turnover dynamics to drive cell motility and organize cytoplasm. Although much is known about how cells control actin polymerization, we do not understand how actin filaments depolymerize inside cells. I briefly describe how the combination of imaging actin filament dynamics in cells and using in vitro biochemistry progressively altered our views of actin depolymerization. I describe why I do not think that the prevailing model of actin filament turnover-cofilin-mediated actin filament severing-can account for actin filament disassembly detected in cells. Finally, I speculate that cells might be able to tune the mechanism of actin depolymerization to meet physiological demands and selectively control the stabilities of different actin arrays.

AB - The actin cytoskeleton is constantly assembling and disassembling. Cells harness the energy of these turnover dynamics to drive cell motility and organize cytoplasm. Although much is known about how cells control actin polymerization, we do not understand how actin filaments depolymerize inside cells. I briefly describe how the combination of imaging actin filament dynamics in cells and using in vitro biochemistry progressively altered our views of actin depolymerization. I describe why I do not think that the prevailing model of actin filament turnover-cofilin-mediated actin filament severing-can account for actin filament disassembly detected in cells. Finally, I speculate that cells might be able to tune the mechanism of actin depolymerization to meet physiological demands and selectively control the stabilities of different actin arrays.

UR - http://www.scopus.com/inward/record.url?scp=84881034194&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84881034194&partnerID=8YFLogxK

U2 - 10.1091/mbc.E12-09-0694

DO - 10.1091/mbc.E12-09-0694

M3 - Review article

C2 - 23900650

AN - SCOPUS:84881034194

VL - 24

SP - 2299

EP - 2302

JO - Molecular Biology of the Cell

JF - Molecular Biology of the Cell

SN - 1059-1524

IS - 15

ER -