Abstract
Macrophage populations exhibit a wide range of antigenic and functional phenotypes, including cytokine production, response to immunomodulatory stimuli, and clearance of pathogens. The expanding clinical exploitation of recombinant growth factors and cytokines with the potential to regulate the production and function of peripheral macrophage populations necessitates an increased understanding of the mechanisms by which functionally distinct macrophage populations arise as well as the ramifications of macrophage heterogeneity. The present review summarizes recent data which supports multiple mechanisms by which heterogeneous macrophage populations arise: 1) differential signals experienced within diverse tissue microenvironments; 2) developmentally-staged expression of specific functions; 3) clonal variation of myeloid progenitor cells; and 4) alternate hematopoietic stimulation. These data show that the above processes are not mutually exclusive and that each likely contributes to the observed heterogeneity of peripheral macrophage populations.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 602-618 |
| Number of pages | 17 |
| Journal | Journal of Leukocyte Biology |
| Volume | 53 |
| Issue number | 5 |
| DOIs | |
| State | Published - Jan 1 1993 |
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Keywords
- cytokines
- cytotoxicity
- differentiation
- myelopoiesis
ASJC Scopus subject areas
- Cell Biology
Cite this
Mechanisms generating functionally heterogeneous macrophages : Chaos revisited. / Rutherford, M. S.; Witsell, A.; Schook, L. B.
In: Journal of Leukocyte Biology, Vol. 53, No. 5, 01.01.1993, p. 602-618.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Mechanisms generating functionally heterogeneous macrophages
T2 - Chaos revisited
AU - Rutherford, M. S.
AU - Witsell, A.
AU - Schook, L. B.
PY - 1993/1/1
Y1 - 1993/1/1
N2 - Macrophage populations exhibit a wide range of antigenic and functional phenotypes, including cytokine production, response to immunomodulatory stimuli, and clearance of pathogens. The expanding clinical exploitation of recombinant growth factors and cytokines with the potential to regulate the production and function of peripheral macrophage populations necessitates an increased understanding of the mechanisms by which functionally distinct macrophage populations arise as well as the ramifications of macrophage heterogeneity. The present review summarizes recent data which supports multiple mechanisms by which heterogeneous macrophage populations arise: 1) differential signals experienced within diverse tissue microenvironments; 2) developmentally-staged expression of specific functions; 3) clonal variation of myeloid progenitor cells; and 4) alternate hematopoietic stimulation. These data show that the above processes are not mutually exclusive and that each likely contributes to the observed heterogeneity of peripheral macrophage populations.
AB - Macrophage populations exhibit a wide range of antigenic and functional phenotypes, including cytokine production, response to immunomodulatory stimuli, and clearance of pathogens. The expanding clinical exploitation of recombinant growth factors and cytokines with the potential to regulate the production and function of peripheral macrophage populations necessitates an increased understanding of the mechanisms by which functionally distinct macrophage populations arise as well as the ramifications of macrophage heterogeneity. The present review summarizes recent data which supports multiple mechanisms by which heterogeneous macrophage populations arise: 1) differential signals experienced within diverse tissue microenvironments; 2) developmentally-staged expression of specific functions; 3) clonal variation of myeloid progenitor cells; and 4) alternate hematopoietic stimulation. These data show that the above processes are not mutually exclusive and that each likely contributes to the observed heterogeneity of peripheral macrophage populations.
KW - cytokines
KW - cytotoxicity
KW - differentiation
KW - myelopoiesis
UR - http://www.scopus.com/inward/record.url?scp=0027241426&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027241426&partnerID=8YFLogxK
U2 - 10.1002/jlb.53.5.602
DO - 10.1002/jlb.53.5.602
M3 - Review article
C2 - 8501399
AN - SCOPUS:0027241426
VL - 53
SP - 602
EP - 618
JO - Journal of Leukocyte Biology
JF - Journal of Leukocyte Biology
SN - 0741-5400
IS - 5
ER -