Mechanism of phospholipid biosynthesis in Escherichia coli: Acyl-CoA synthetase is not required for the incorporation of intracellular free fatty acids into phospholipid

Tapas K. Ray, John E. Cronan

Research output: Contribution to journalArticlepeer-review

Abstract

Previous results have shown that acyl-CoA synthetase is required both for the incorporation of exogenous fatty acids into the phospholipids of E. coli and for the transport of fatty acids into the cell. We have demonstrated that acyl-CoA synthetase is not required for the incorporation of intracellular free fatty acids into phospholipid. This finding indicates that the role of this enzyme in the incorporation of exogenously supplied fatty acids is primarily at the level of fatty acid transport.

Original languageEnglish (US)
Pages (from-to)506-513
Number of pages8
JournalBiochemical and Biophysical Research Communications
Volume69
Issue number2
DOIs
StatePublished - Mar 22 1976
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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