Mechanism of homophilic cadherin adhesion

Deborah Leckband, Sanjeevi Sivasankar

Research output: Contribution to journalReview articlepeer-review


Direct measurements of the distance-dependent forces between membrane-bound cadherins were used to test current models of homophilic cadherin interactions. The results reveal a complex binding mechanism in which the proteins adhere in multiple alignments that involve more than the amino-terminal domains.

Original languageEnglish (US)
Pages (from-to)587-592
Number of pages6
JournalCurrent Opinion in Cell Biology
Issue number5
StatePublished - 2000

ASJC Scopus subject areas

  • Cell Biology


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