Mechanism of exercise-induced augmentation of lymphokine activated killer (LAK) cell activity in the horse

D. W. Horohov; T. L. Keadle; S. S. Pourciau; M. A. Littlefield-Chabaud; S. G. Kamerling; M. L. Keowen; D. D. French; P. A. Melrose

doi:10.1016/S0165-2427(96)05610-3

Mechanism of exercise-induced augmentation of lymphokine activated killer (LAK) cell activity in the horse

D. W. Horohov, T. L. Keadle, S. S. Pourciau, M. A. Littlefield-Chabaud, S. G. Kamerling, M. L. Keowen, D. D. French, P. A. Melrose

Research output: Contribution to journal › Article › peer-review

Abstract

Intense exercise affects various parameters of the immune system. The overall effect of exercise on immune function is dependent upon the physical condition of the subject, the intensity and duration of the exercise period, and the immune parameter assessed. Unconditioned horses subjected to a single bout of intensive exercise exhibit multiple alterations in immune function, including an augmentation of lymphokine activated killer (LAK) cell function. This increase in LAK cell activity is not due to an increase in circulating LAK precursors. While peripheral blood mononuclear cells from exercising horses exhibit greater responsiveness to IL-2, this is not due to an increase in IL-2 receptor expression, LAK cell generation in vitro is augmented by those catecholamines and neuropeptides which are produced during exercise, suggesting a direct effect of these compounds on LAK cell generation at a step post IL-2 receptor binding.

Original language	English (US)
Pages (from-to)	221-233
Number of pages	13
Journal	Veterinary Immunology and Immunopathology
Volume	53
Issue number	3-4
DOIs	https://doi.org/10.1016/S0165-2427(96)05610-3
State	Published - Oct 1996
Externally published	Yes

Keywords

Horse
IL-2
Immune system
LAK

ASJC Scopus subject areas

Immunology
General Veterinary

Online availability

10.1016/S0165-2427(96)05610-3

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title = "Mechanism of exercise-induced augmentation of lymphokine activated killer (LAK) cell activity in the horse",

abstract = "Intense exercise affects various parameters of the immune system. The overall effect of exercise on immune function is dependent upon the physical condition of the subject, the intensity and duration of the exercise period, and the immune parameter assessed. Unconditioned horses subjected to a single bout of intensive exercise exhibit multiple alterations in immune function, including an augmentation of lymphokine activated killer (LAK) cell function. This increase in LAK cell activity is not due to an increase in circulating LAK precursors. While peripheral blood mononuclear cells from exercising horses exhibit greater responsiveness to IL-2, this is not due to an increase in IL-2 receptor expression, LAK cell generation in vitro is augmented by those catecholamines and neuropeptides which are produced during exercise, suggesting a direct effect of these compounds on LAK cell generation at a step post IL-2 receptor binding.",

keywords = "Horse, IL-2, Immune system, LAK",

author = "Horohov, {D. W.} and Keadle, {T. L.} and Pourciau, {S. S.} and Littlefield-Chabaud, {M. A.} and Kamerling, {S. G.} and Keowen, {M. L.} and French, {D. D.} and Melrose, {P. A.}",

note = "Funding Information: The generous support from the Grayson Jockey Club, Inc. and the Equine Veterinary Research Program of the LSU School of Veterinary Medicine are gratefully acknowledged. TLK was supported through a LSU Board of Reagents Scholarship.",

year = "1996",

month = oct,

doi = "10.1016/S0165-2427(96)05610-3",

language = "English (US)",

volume = "53",

pages = "221--233",

journal = "Veterinary Immunology and Immunopathology",

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AU - Horohov, D. W.

AU - Keadle, T. L.

AU - Pourciau, S. S.

AU - Littlefield-Chabaud, M. A.

AU - Kamerling, S. G.

AU - Keowen, M. L.

AU - French, D. D.

AU - Melrose, P. A.

N1 - Funding Information: The generous support from the Grayson Jockey Club, Inc. and the Equine Veterinary Research Program of the LSU School of Veterinary Medicine are gratefully acknowledged. TLK was supported through a LSU Board of Reagents Scholarship.

PY - 1996/10

Y1 - 1996/10

N2 - Intense exercise affects various parameters of the immune system. The overall effect of exercise on immune function is dependent upon the physical condition of the subject, the intensity and duration of the exercise period, and the immune parameter assessed. Unconditioned horses subjected to a single bout of intensive exercise exhibit multiple alterations in immune function, including an augmentation of lymphokine activated killer (LAK) cell function. This increase in LAK cell activity is not due to an increase in circulating LAK precursors. While peripheral blood mononuclear cells from exercising horses exhibit greater responsiveness to IL-2, this is not due to an increase in IL-2 receptor expression, LAK cell generation in vitro is augmented by those catecholamines and neuropeptides which are produced during exercise, suggesting a direct effect of these compounds on LAK cell generation at a step post IL-2 receptor binding.

AB - Intense exercise affects various parameters of the immune system. The overall effect of exercise on immune function is dependent upon the physical condition of the subject, the intensity and duration of the exercise period, and the immune parameter assessed. Unconditioned horses subjected to a single bout of intensive exercise exhibit multiple alterations in immune function, including an augmentation of lymphokine activated killer (LAK) cell function. This increase in LAK cell activity is not due to an increase in circulating LAK precursors. While peripheral blood mononuclear cells from exercising horses exhibit greater responsiveness to IL-2, this is not due to an increase in IL-2 receptor expression, LAK cell generation in vitro is augmented by those catecholamines and neuropeptides which are produced during exercise, suggesting a direct effect of these compounds on LAK cell generation at a step post IL-2 receptor binding.

KW - Horse

KW - IL-2

KW - Immune system

KW - LAK

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ER -

Mechanism of exercise-induced augmentation of lymphokine activated killer (LAK) cell activity in the horse

Abstract

Keywords

ASJC Scopus subject areas

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