Mechanism for food avoidance learning in the central pattern generator of feeding behavior of Pleurobranchaea californica

J. A. London, Rhanor Gillette

Research output: Contribution to journalArticle

Abstract

Food-avoidance conditioning in the mollusk Pleurobranchaea results in suppression of the feeding response to food stimuli. In conditioned animals, identified interneurons of the central pattern generator (CPG) for feeding behavior, the Int-2s, respond to a food stimulus with greater and more long-lasting excitation than controls. Enhanced Int-2 responsiveness to food stimuli is associated with markedly heightened Int-2 excitability. Sustained activity in the Int-2s arrests motor output of the oscillatory CPG in the protraction/retraction movement cycle of feeding through tonic excitation of a population of retractor interneurons and inhibition of protractors. The CPG locus of the learning mechanism is permissive of sensory excitation of alternative behavior and leaves the possibility open for release of the suppressed behavior in a fully aroused state.

Original languageEnglish (US)
Pages (from-to)4058-4062
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume83
Issue number11
DOIs
StatePublished - Jan 1 1986

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Pleurobranchaea
Central Pattern Generators
Avoidance Learning
Feeding Behavior
Food
Interneurons
Mollusca
Learning
Population

ASJC Scopus subject areas

  • General

Cite this

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abstract = "Food-avoidance conditioning in the mollusk Pleurobranchaea results in suppression of the feeding response to food stimuli. In conditioned animals, identified interneurons of the central pattern generator (CPG) for feeding behavior, the Int-2s, respond to a food stimulus with greater and more long-lasting excitation than controls. Enhanced Int-2 responsiveness to food stimuli is associated with markedly heightened Int-2 excitability. Sustained activity in the Int-2s arrests motor output of the oscillatory CPG in the protraction/retraction movement cycle of feeding through tonic excitation of a population of retractor interneurons and inhibition of protractors. The CPG locus of the learning mechanism is permissive of sensory excitation of alternative behavior and leaves the possibility open for release of the suppressed behavior in a fully aroused state.",
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