Mechanical response of single living cells by bio-mems sensors

Shengyuan Yang, M Taher A Saif

Research output: Contribution to journalConference article

Abstract

The paper presents a new bio-MEMS sensor for in-situ force response measurement of single living cells. The sensor consists of fixed-fixed silicon beams connected by a backbone and attached to a probe. The sensor is functionalized by a coating with fibronectin. Adhesion sites are formed between the probe and a single cell by contact. The cell is stretched by the probe and the cell force response is measured from the deflection of the beams and their spring constant. Several living monkey fibroblast cells are tested as they are loaded and unloaded under large deformation. The force response is found to be linear and reversible.

Original languageEnglish (US)
Pages (from-to)265-267
Number of pages3
JournalProceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
StatePublished - Jul 19 2004
Event17th IEEE International Conference on Micro Electro Mechanical Systems (MEMS): Maastricht MEMS 2004 Technical Digest - Maastricht, Netherlands
Duration: Jan 25 2004Jan 29 2004

Fingerprint

Cells
probes
sensors
Sensors
cells
monkeys
fibroblasts
Silicon
Fibroblasts
Fibronectins
microelectromechanical systems
MEMS
deflection
adhesion
Adhesion
coatings
Coatings
silicon

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Mechanical Engineering
  • Electrical and Electronic Engineering

Cite this

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