Mechanical communication between cardiac cell leads to synchrony in beating

Xin Tang, Piyush Bajaj, Rashid Bashir, Taher Saif

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

It is generally understood that cardiac cells synchronize their beating through electro-chemical signalling. Here we show, theoretically and experimentally, that isolated cardiac cells can communicate with each other through an intervening deformable media. Such communication leads to coupled dynamics and emergence of synchronous beating. The interaction between the cells depends inversely with the elastic modulus of the media, and the distance between them. This finding may explain asynchronous beating of the atrium in patients with atrial fibrillation where the stiffness of the atrial wall becomes significantly harder due to fibrosis [1].

Original languageEnglish (US)
Title of host publicationASME 2012 Summer Bioengineering Conference, SBC 2012
Pages333-334
Number of pages2
DOIs
StatePublished - Dec 1 2012
EventASME 2012 Summer Bioengineering Conference, SBC 2012 - Fajardo, Puerto Rico
Duration: Jun 20 2012Jun 23 2012

Publication series

NameASME 2012 Summer Bioengineering Conference, SBC 2012

Other

OtherASME 2012 Summer Bioengineering Conference, SBC 2012
CountryPuerto Rico
CityFajardo
Period6/20/126/23/12

ASJC Scopus subject areas

  • Bioengineering

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  • Cite this

    Tang, X., Bajaj, P., Bashir, R., & Saif, T. (2012). Mechanical communication between cardiac cell leads to synchrony in beating. In ASME 2012 Summer Bioengineering Conference, SBC 2012 (pp. 333-334). (ASME 2012 Summer Bioengineering Conference, SBC 2012). https://doi.org/10.1115/SBC2012-80937