TY - JOUR
T1 - Measuring the COVID-19 Mortality Burden in the United States
T2 - A Microsimulation Study
AU - Reif, Julian
AU - Heun-Johnson, Hanke
AU - Tysinger, Bryan
AU - Lakdawalla, Darius
N1 - Publisher Copyright:
© 2021 American College of Physicians
PY - 2021/12/1
Y1 - 2021/12/1
N2 - Background: Fully assessing the mortality burden of the COVID-19 pandemic requires measuring years of life lost (YLLs) and accounting for quality-of-life differences. Objective: To measure YLLs and quality-adjusted life-years (QALYs) lost from the COVID-19 pandemic, by age, sex, race/ethnicity, and comorbidity. Design: State-transition microsimulation model. Data Sources: Health and Retirement Study, Panel Study of Income Dynamics, data on excess deaths from the Centers for Disease Control and Prevention, and nursing home death counts from the Centers for Medicare & Medicaid Services. Target Population: U.S. population aged 25 years and older. Time Horizon: Lifetime. Perspective: Individual. Intervention: COVID-19 pandemic through 13 March 2021. Outcome Measures: YLLs and QALYs lost per 10 000 persons in the population. The estimates account for the age, sex, and race/ethnicity of decedents, along with obesity, smoking behavior, lung disease, heart disease, diabetes, cancer, stroke, hypertension, dementia, and nursing home residence. Results of Base-Case Analysis: The COVID-19 pandemic resulted in 6.62 million QALYs lost (9.08 million YLLs) through 13 March 2021, with 3.6 million (54%) lost by those aged 25 to 64 years. The greatest toll was on Black and Hispanic communities, especially among men aged 65 years or older, who lost 1138 and 1371 QALYs, respectively, per 10 000 persons. Absent the pandemic, 38% of decedents would have had average or above-average life expectancies for their subgroup defined by age, sex, and race/ethnicity. Results of Sensitivity Analysis: Accounting for uncertainty in risk factors for death from COVID-19 yielded similar results. Limitation: Estimates may vary depending on assumptions about mortality and quality-of-life projections. Conclusion: Beyond excess deaths alone, the COVID-19 pandemic imposed a greater life expectancy burden on persons aged 25 to 64 years, including those with average or above-average life expectancies, and a disproportionate burden on Black and Hispanic communities.
AB - Background: Fully assessing the mortality burden of the COVID-19 pandemic requires measuring years of life lost (YLLs) and accounting for quality-of-life differences. Objective: To measure YLLs and quality-adjusted life-years (QALYs) lost from the COVID-19 pandemic, by age, sex, race/ethnicity, and comorbidity. Design: State-transition microsimulation model. Data Sources: Health and Retirement Study, Panel Study of Income Dynamics, data on excess deaths from the Centers for Disease Control and Prevention, and nursing home death counts from the Centers for Medicare & Medicaid Services. Target Population: U.S. population aged 25 years and older. Time Horizon: Lifetime. Perspective: Individual. Intervention: COVID-19 pandemic through 13 March 2021. Outcome Measures: YLLs and QALYs lost per 10 000 persons in the population. The estimates account for the age, sex, and race/ethnicity of decedents, along with obesity, smoking behavior, lung disease, heart disease, diabetes, cancer, stroke, hypertension, dementia, and nursing home residence. Results of Base-Case Analysis: The COVID-19 pandemic resulted in 6.62 million QALYs lost (9.08 million YLLs) through 13 March 2021, with 3.6 million (54%) lost by those aged 25 to 64 years. The greatest toll was on Black and Hispanic communities, especially among men aged 65 years or older, who lost 1138 and 1371 QALYs, respectively, per 10 000 persons. Absent the pandemic, 38% of decedents would have had average or above-average life expectancies for their subgroup defined by age, sex, and race/ethnicity. Results of Sensitivity Analysis: Accounting for uncertainty in risk factors for death from COVID-19 yielded similar results. Limitation: Estimates may vary depending on assumptions about mortality and quality-of-life projections. Conclusion: Beyond excess deaths alone, the COVID-19 pandemic imposed a greater life expectancy burden on persons aged 25 to 64 years, including those with average or above-average life expectancies, and a disproportionate burden on Black and Hispanic communities.
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U2 - 10.7326/M21-2239
DO - 10.7326/M21-2239
M3 - Article
C2 - 34543588
AN - SCOPUS:85122903447
SN - 0003-4819
VL - 174
SP - 1700
EP - 1709
JO - Annals of internal medicine
JF - Annals of internal medicine
IS - 12
ER -