MDS-UPDRS to assess non-motor symptoms after STN DBS for Parkinson's disease

Nickey Jafari, Rajesh Pahwa, Jules M. Nazzaro, Paul M. Arnold, Kelly E. Lyons

Research output: Contribution to journalArticlepeer-review


Objective: To determine if the non-motor sections of the Movement Disorder Society's (MDS) version of the Unified Parkinson's Disease Rating Scale (UPDRS) could supplement the original UPDRS as a patient completed assessment of changes in non-motor symptoms in Parkinson's disease (PD) patients after bilateral subthalamic nucleus (STN) deep brain stimulation (DBS). Methods: Thirty PD patients who underwent bilateral STN DBS were assessed using the total UPDRS and the non-motor sections of the MDS-UPDRS prior to surgery and one year following surgery. This study focuses on non-motor symptoms as assessed by Part I of the UPDRS and Part 1A and 1B of the MDS-UPDRS. Results: One year following surgery, no individual non-motor symptoms or the total mentation score of the UPDRS were significantly changed. In comparison, the MDS-UPDRS showed significant improvements in sleep and urinary problems and a trend towards improvement in anxiety, constipation, daytime sleepiness, fatigue and pain. Conclusions: This study provides evidence that the MDS-UPDRS non-motor sections, when completed by the patients, can supplement the original version of the UPDRS as an effective method of measuring changes in non-motor symptoms after DBS. It also reinforces the benefits of bilateral STN DBS on non-motor symptoms of PD.

Original languageEnglish (US)
Pages (from-to)25-29
Number of pages5
JournalInternational Journal of Neuroscience
Issue number1
StatePublished - Jan 2 2016
Externally publishedYes


  • Parkinson's disease
  • deep brain stimulation
  • non-motor symptoms
  • subthalamic nucleus

ASJC Scopus subject areas

  • General Neuroscience


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