Mathematical Models of Human African Trypanosomiasis Epidemiology

Kat S. Rock, Chris M. Stone, Ian M. Hastings, Matt J. Keeling, Steve J. Torr, Nakul Chitnis

Research output: Contribution to journalArticlepeer-review


Human African trypanosomiasis (HAT), commonly called sleeping sickness, is caused by Trypanosoma spp. and transmitted by tsetse flies (. Glossina spp.). HAT is usually fatal if untreated and transmission occurs in foci across sub-Saharan Africa. Mathematical modelling of HAT began in the 1980s with extensions of the Ross-Macdonald malaria model and has since consisted, with a few exceptions, of similar deterministic compartmental models. These models have captured the main features of HAT epidemiology and provided insight on the effectiveness of the two main control interventions (treatment of humans and tsetse fly control) in eliminating transmission. However, most existing models have overestimated prevalence of infection and ignored transient dynamics. There is a need for properly validated models, evolving with improved data collection, that can provide quantitative predictions to help guide control and elimination strategies for HAT.

Original languageEnglish (US)
Pages (from-to)53-133
Number of pages81
JournalAdvances in Parasitology
StatePublished - Mar 1 2015
Externally publishedYes


  • Human African trypanosomiasis
  • Mathematical epidemiology
  • Mathematical modelling
  • Sleeping sickness
  • Tsetse flies

ASJC Scopus subject areas

  • Parasitology


Dive into the research topics of 'Mathematical Models of Human African Trypanosomiasis Epidemiology'. Together they form a unique fingerprint.

Cite this