(equation presented) We describe an equilibrium model to determine whether a random population of dynamic copolymer sequences could be driven by molecular recognition to a subset of sequences that tightly bind a specific ligand. The model predicts that the population's mean binding constant can be shifted, but because of competitive binding, only to a limited degree (ca. 2 orders of magnitude larger than the original mean). True chemical evolution will require a mechanism for selection and amplification.

Original languageEnglish (US)
Pages (from-to)915-918
Number of pages4
JournalOrganic Letters
Issue number7
StatePublished - Apr 6 2000

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


Dive into the research topics of '"Masterpiece" copolymer sequences by targeted equilibrium-shifting'. Together they form a unique fingerprint.

Cite this