Mass spectrometric survey of interganglionically transported peptides in Aplysia

Lingjun Li, Tatiana P. Moroz, Rebecca W. Garden, Philip D. Floyd, Klaudiusz R. Weiss, Jonathan V. Sweedler

Research output: Contribution to journalArticlepeer-review


The major ganglionic connectives in Aplysia are assayed to determine putative neuropeptides. Matrix-assisted laser desorption/ionization mass spectrometry allows direct measurement of peptides in a nerve. Many previously characterized peptides are observed, including APGWamide, buccalins, small cardioactive peptides, and egg-laying hormone. Several unreported peptides are detected in specific nerves, suggesting they may have important physiological roles. Furthermore, novel processing products of the L5-67 precursor peptide and the APGWamide/cerebral peptide 1 prohormone are strongly suggested, and their interganglionic transport demonstrated.

Original languageEnglish (US)
Pages (from-to)1425-1433
Number of pages9
Issue number8
StatePublished - 1998


  • Aplysia californica
  • Cerebral peptide I (CPI)
  • Interganglionic transport
  • Mass spectrometry (MS)
  • Matrix-assisted laser desorption/ionization (MALDI)
  • Neuropeptide
  • Peptide processing

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience


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