Marr’s influence on the standard model of hippocampus, and the need for more theoretical advances

Michael E. Hasselmo, James R. Hinman

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

David Marr’s classic 1971 paper laid the foundation for a standard model of the hippocampus combining pattern separation (Marr’s codon hypothesis) and pattern completion. His paper discusses functions that became components of a standard theoretical model of hippocampal function within the field, and inspired further studies on more detailed analysis of pattern separation in the dentate gyrus and pattern completion by attractor dynamics in region CA3. This theoretical framework has been the focus of a number of experimental tests over the years, including neurophysiological studies of patterns of neuronal activity in behaving rats, tests of behavioural effects with selective genetic manipulations, and fMRI studies of hippocampal activity in humans. This chapter also reviews subsequent research related to the dynamics of pattern completion, as well as subsequent modeling that addressed network dynamics in the hippocampus including theta rhythm oscillations, theta phase precession and the patterns of grid cell firing in entorhinal cortex. Finally, this chapter addresses the need for future breakthroughs by researchers that combine sophisticated mathematical techniques with detailed knowledge of the anatomy and neurophysiology of cortical structures.

Original languageEnglish (US)
Title of host publicationComputational Theories and their Implementation in the Brain
Subtitle of host publicationThe Legacy of David Marr
PublisherOxford University Press
Pages133-158
Number of pages26
ISBN (Electronic)9780198749783
DOIs
StatePublished - Jan 1 2017
Externally publishedYes

Keywords

  • Associative memory
  • Codon hypothesis
  • Dentate gyrus
  • Encoding
  • Grid cells
  • Pattern completion
  • Pattern separation
  • Region CA3
  • Retrieval
  • Sequence encoding
  • Theta rhythm

ASJC Scopus subject areas

  • Psychology(all)

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