Mapping of the gene for the mel1a-melatonin receptor to human chromosome 4 (MTNR1A) and mouse chromosome 8 (MTNR1A)

Susan A. Slaugenhaupt; Alfred L. Roca; Christopher B. Liebert; Michael R. Altherr; James F. Gusella; Steven M. Reppert

doi:10.1006/geno.1995.1056

Mapping of the gene for the mel_1a-melatonin receptor to human chromosome 4 (MTNR1A) and mouse chromosome 8 (MTNR1A)

Susan A. Slaugenhaupt, Alfred L. Roca, Christopher B. Liebert, Michael R. Altherr, James F. Gusella, Steven M. Reppert

Research output: Contribution to journal › Article › peer-review

Abstract

The pineal hormone melatonin elicits potent circadian and reproductive effects in mammals. We report the chromosomal location of the gene for the Mel_1a-melatonin receptor that likely mediates these circadian and reproductive actions. PCR analysis of human-rodent somatic cell hybrids showed that the receptor gene (MTNR1A) maps to human chromosome 4q35.1. An interspecific backcross analysis revealed that the mouse gene (Mtnr1a) maps to the proximal portion of chromosome 8. These loci may be involved in genetically based circadian and neuroendocrine disorders.

Original language	English (US)
Pages (from-to)	355-357
Number of pages	3
Journal	Genomics
Volume	27
Issue number	2
DOIs	https://doi.org/10.1006/geno.1995.1056
State	Published - May 20 1995
Externally published	Yes

ASJC Scopus subject areas

Genetics

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10.1006/geno.1995.1056

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title = "Mapping of the gene for the mel1a-melatonin receptor to human chromosome 4 (MTNR1A) and mouse chromosome 8 (MTNR1A)",

abstract = "The pineal hormone melatonin elicits potent circadian and reproductive effects in mammals. We report the chromosomal location of the gene for the Mel1a-melatonin receptor that likely mediates these circadian and reproductive actions. PCR analysis of human-rodent somatic cell hybrids showed that the receptor gene (MTNR1A) maps to human chromosome 4q35.1. An interspecific backcross analysis revealed that the mouse gene (Mtnr1a) maps to the proximal portion of chromosome 8. These loci may be involved in genetically based circadian and neuroendocrine disorders.",

author = "Slaugenhaupt, {Susan A.} and Roca, {Alfred L.} and Liebert, {Christopher B.} and Altherr, {Michael R.} and Gusella, {James F.} and Reppert, {Steven M.}",

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AU - Slaugenhaupt, Susan A.

AU - Roca, Alfred L.

AU - Liebert, Christopher B.

AU - Altherr, Michael R.

AU - Gusella, James F.

AU - Reppert, Steven M.

PY - 1995/5/20

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AB - The pineal hormone melatonin elicits potent circadian and reproductive effects in mammals. We report the chromosomal location of the gene for the Mel1a-melatonin receptor that likely mediates these circadian and reproductive actions. PCR analysis of human-rodent somatic cell hybrids showed that the receptor gene (MTNR1A) maps to human chromosome 4q35.1. An interspecific backcross analysis revealed that the mouse gene (Mtnr1a) maps to the proximal portion of chromosome 8. These loci may be involved in genetically based circadian and neuroendocrine disorders.

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