Mapping of the gene for the mel1a-melatonin receptor to human chromosome 4 (MTNR1A) and mouse chromosome 8 (MTNR1A)

Susan A. Slaugenhaupt, Alfred L. Roca, Christopher B. Liebert, Michael R. Altherr, James F. Gusella, Steven M. Reppert

Research output: Contribution to journalArticlepeer-review


The pineal hormone melatonin elicits potent circadian and reproductive effects in mammals. We report the chromosomal location of the gene for the Mel1a-melatonin receptor that likely mediates these circadian and reproductive actions. PCR analysis of human-rodent somatic cell hybrids showed that the receptor gene (MTNR1A) maps to human chromosome 4q35.1. An interspecific backcross analysis revealed that the mouse gene (Mtnr1a) maps to the proximal portion of chromosome 8. These loci may be involved in genetically based circadian and neuroendocrine disorders.

Original languageEnglish (US)
Pages (from-to)355-357
Number of pages3
Issue number2
StatePublished - May 20 1995
Externally publishedYes

ASJC Scopus subject areas

  • Genetics

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