Mapping of KIT adjacent sequences on canid autosomes and B chromosomes

D. V. Yudkin, V. A. Trifonov, A. V. Kukekova, N. V. Vorobieva, N. V. Rubtsova, F. Yang, G. M. Acland, M. A. Ferguson-Smith, A. S. Graphodatsky

Research output: Contribution to journalArticle

Abstract

B chromosomes are often considered to be one of the most mysterious elements of karyotypes (Camacho, 2004). It is generally believed that mammalian B chromosomes do not contain any protein coding genes. The discovery of a conserved KIT gene in Canidae B chromosomes has changed this view. Here we performed analysis of sequences surrounding KIT in B chromosomes of the fox and raccoon dog. The presence of the RPL23A pseudogene was shown in canid B chromosomes. The 3′ end fragment of the KDR gene was found in raccoon dog B chromosomes. The size of the B-specific fragment homologous to the autosome fragment was estimated to be a minimum of 480 kbp in both species. The origin and evolution of B chromosomes in Canidae are discussed.

Original languageEnglish (US)
Pages (from-to)100-103
Number of pages4
JournalCytogenetic and Genome Research
Volume116
Issue number1-2
DOIs
StatePublished - Jan 2007
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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    Yudkin, D. V., Trifonov, V. A., Kukekova, A. V., Vorobieva, N. V., Rubtsova, N. V., Yang, F., Acland, G. M., Ferguson-Smith, M. A., & Graphodatsky, A. S. (2007). Mapping of KIT adjacent sequences on canid autosomes and B chromosomes. Cytogenetic and Genome Research, 116(1-2), 100-103. https://doi.org/10.1159/000097424