Mapping of KIT adjacent sequences on canid autosomes and B chromosomes

D. V. Yudkin; V. A. Trifonov; A. V. Kukekova; N. V. Vorobieva; N. V. Rubtsova; F. Yang; G. M. Acland; M. A. Ferguson-Smith; A. S. Graphodatsky

doi:10.1159/000097424

Mapping of KIT adjacent sequences on canid autosomes and B chromosomes

D. V. Yudkin, V. A. Trifonov, A. V. Kukekova, N. V. Vorobieva, N. V. Rubtsova, F. Yang, G. M. Acland, M. A. Ferguson-Smith, A. S. Graphodatsky

Research output: Contribution to journal › Article › peer-review

Abstract

B chromosomes are often considered to be one of the most mysterious elements of karyotypes (Camacho, 2004). It is generally believed that mammalian B chromosomes do not contain any protein coding genes. The discovery of a conserved KIT gene in Canidae B chromosomes has changed this view. Here we performed analysis of sequences surrounding KIT in B chromosomes of the fox and raccoon dog. The presence of the RPL23A pseudogene was shown in canid B chromosomes. The 3′ end fragment of the KDR gene was found in raccoon dog B chromosomes. The size of the B-specific fragment homologous to the autosome fragment was estimated to be a minimum of 480 kbp in both species. The origin and evolution of B chromosomes in Canidae are discussed.

Original language	English (US)
Pages (from-to)	100-103
Number of pages	4
Journal	Cytogenetic and Genome Research
Volume	116
Issue number	1-2
DOIs	https://doi.org/10.1159/000097424
State	Published - Jan 2007
Externally published	Yes

ASJC Scopus subject areas

Molecular Biology
Genetics
Genetics(clinical)

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10.1159/000097424

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title = "Mapping of KIT adjacent sequences on canid autosomes and B chromosomes",

abstract = "B chromosomes are often considered to be one of the most mysterious elements of karyotypes (Camacho, 2004). It is generally believed that mammalian B chromosomes do not contain any protein coding genes. The discovery of a conserved KIT gene in Canidae B chromosomes has changed this view. Here we performed analysis of sequences surrounding KIT in B chromosomes of the fox and raccoon dog. The presence of the RPL23A pseudogene was shown in canid B chromosomes. The 3′ end fragment of the KDR gene was found in raccoon dog B chromosomes. The size of the B-specific fragment homologous to the autosome fragment was estimated to be a minimum of 480 kbp in both species. The origin and evolution of B chromosomes in Canidae are discussed.",

author = "Yudkin, {D. V.} and Trifonov, {V. A.} and Kukekova, {A. V.} and Vorobieva, {N. V.} and Rubtsova, {N. V.} and F. Yang and Acland, {G. M.} and Ferguson-Smith, {M. A.} and Graphodatsky, {A. S.}",

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language = "English (US)",

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journal = "Cytogenetic and Genome Research",

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AU - Yudkin, D. V.

AU - Trifonov, V. A.

AU - Kukekova, A. V.

AU - Vorobieva, N. V.

AU - Rubtsova, N. V.

AU - Yang, F.

AU - Acland, G. M.

AU - Ferguson-Smith, M. A.

AU - Graphodatsky, A. S.

PY - 2007/1

Y1 - 2007/1

N2 - B chromosomes are often considered to be one of the most mysterious elements of karyotypes (Camacho, 2004). It is generally believed that mammalian B chromosomes do not contain any protein coding genes. The discovery of a conserved KIT gene in Canidae B chromosomes has changed this view. Here we performed analysis of sequences surrounding KIT in B chromosomes of the fox and raccoon dog. The presence of the RPL23A pseudogene was shown in canid B chromosomes. The 3′ end fragment of the KDR gene was found in raccoon dog B chromosomes. The size of the B-specific fragment homologous to the autosome fragment was estimated to be a minimum of 480 kbp in both species. The origin and evolution of B chromosomes in Canidae are discussed.

AB - B chromosomes are often considered to be one of the most mysterious elements of karyotypes (Camacho, 2004). It is generally believed that mammalian B chromosomes do not contain any protein coding genes. The discovery of a conserved KIT gene in Canidae B chromosomes has changed this view. Here we performed analysis of sequences surrounding KIT in B chromosomes of the fox and raccoon dog. The presence of the RPL23A pseudogene was shown in canid B chromosomes. The 3′ end fragment of the KDR gene was found in raccoon dog B chromosomes. The size of the B-specific fragment homologous to the autosome fragment was estimated to be a minimum of 480 kbp in both species. The origin and evolution of B chromosomes in Canidae are discussed.

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Mapping of KIT adjacent sequences on canid autosomes and B chromosomes

Abstract

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