Maple syrup urine disease in a central Indiana hereford herd

Mark E. Robarge; Jonathan E. Beever; Stephen D. Lenz; Christopher J. Lynch; William L. Wigle

doi:10.1155/2015/204037

Maple syrup urine disease in a central Indiana hereford herd

Mark E. Robarge, Jonathan E. Beever, Stephen D. Lenz, Christopher J. Lynch, William L. Wigle

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Abstract

Maple syrup urine disease (MSUD) and further cases were identified in herd mates of a small Hereford herd in Indiana based on history, clinical signs, microscopic lesions, and biochemical and genetic testing. This aminoacidopathy has been diagnosed in polled Shorthorn, polledHereford, andHereford cattle in Australia, Uruguay, Argentina, and Canada and is the result of amutation of the branched-chain alpha-ketoacid dehydrogenase complex. The Indiana index calf case was confirmed by showing the classic accumulation of ketoacids in liver that results from a defect in the E1-alpha subunit (248 C/T haplotype) in the mitochondrial branched-chain α-ketoacid dehydrogenase complex. The presence of the mutation was confirmed in the index case, the dam, and four related herd mates that represent the first confirmed cases of bovine MSUD mutation in United States cattle. c 2015 Mark E. Robarge et al.

Original language	English (US)
Article number	204037
Journal	Case Reports in Veterinary Medicine
Volume	2015
DOIs	https://doi.org/10.1155/2015/204037
State	Published - 2015

ASJC Scopus subject areas

General Veterinary

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abstract = "Maple syrup urine disease (MSUD) and further cases were identified in herd mates of a small Hereford herd in Indiana based on history, clinical signs, microscopic lesions, and biochemical and genetic testing. This aminoacidopathy has been diagnosed in polled Shorthorn, polledHereford, andHereford cattle in Australia, Uruguay, Argentina, and Canada and is the result of amutation of the branched-chain alpha-ketoacid dehydrogenase complex. The Indiana index calf case was confirmed by showing the classic accumulation of ketoacids in liver that results from a defect in the E1-alpha subunit (248 C/T haplotype) in the mitochondrial branched-chain α-ketoacid dehydrogenase complex. The presence of the mutation was confirmed in the index case, the dam, and four related herd mates that represent the first confirmed cases of bovine MSUD mutation in United States cattle. c 2015 Mark E. Robarge et al.",

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AU - Robarge, Mark E.

AU - Beever, Jonathan E.

AU - Lenz, Stephen D.

AU - Lynch, Christopher J.

AU - Wigle, William L.

PY - 2015

Y1 - 2015

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AB - Maple syrup urine disease (MSUD) and further cases were identified in herd mates of a small Hereford herd in Indiana based on history, clinical signs, microscopic lesions, and biochemical and genetic testing. This aminoacidopathy has been diagnosed in polled Shorthorn, polledHereford, andHereford cattle in Australia, Uruguay, Argentina, and Canada and is the result of amutation of the branched-chain alpha-ketoacid dehydrogenase complex. The Indiana index calf case was confirmed by showing the classic accumulation of ketoacids in liver that results from a defect in the E1-alpha subunit (248 C/T haplotype) in the mitochondrial branched-chain α-ketoacid dehydrogenase complex. The presence of the mutation was confirmed in the index case, the dam, and four related herd mates that represent the first confirmed cases of bovine MSUD mutation in United States cattle. c 2015 Mark E. Robarge et al.

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Maple syrup urine disease in a central Indiana hereford herd

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